Imatinib for the treament of patients with unresectable and/or metastatic GIST: systematic review and economic evaluation

Wilson J, Connock M, Song F, Yao G, Fry-Smith A, Raftery J, Peake D.
Health Technol Assess 2005 July; 9(25):1-142.
PMID 15985189
Entrez PubMed

Changing phenotype of gastrointestinal stromal tumours under imatinib mesylate treatment: a potential diagnostic pitfall.

Pauwels P, Debiec-Rychter M, Stul M, De Wever I, Van Oosterom AT, Sciot R.
Histopathology. 2005 Jul;47(1):41-7.
PMID: 15982322
This paper provides striking examples of how GISTs can mutate and change characteristics during imatinib treatment.
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Pregnancy under treatment of imatinib and successful labor in a patient with chronic myelogenous leukemia (CML) Outcome of discontinuation of imatinib

Ali R, Ozkalemkas F, Ozcelik T, Ozkocaman V, Ozan U, Kimya Y, Koksal N, Gulten T, Yakut T, Tunali A.
Leuk Res. 2005 Aug;29(8):971-973. Epub 2005 Feb 16.
Although this case history involved a patient with CML, it is relevant to pregnancy in GIST patients treated with Gleevec.
PMID: 15978950
Entrez PubMed

Phase II study of 9-nitro-camptothecin in patients with advanced chordoma or soft tissue sarcoma.

Chugh R, Dunn R, Zalupski MM, Biermann JS, Sondak VK, Mace JR, Leu KM, Chandler WF, Baker LH.
J Clin Oncol. 2005 May 20;23(15):3597-604.
PMID: 15908670
This Phase II trial report showed no benefit to GIST patients.
Entrez PubMed

Gastrointestinal stromal tumour treated with neoadjuvant imatinib

Loughrey MB, Mitchell C, Mann GB, Michael M, Waring PM.
J Clin Pathol. 2005 Jul;58(7):779-81.
PMID 15976351
Entrez PubMed

Chronic Imatinib Mesylate Exposure Leads to Reduced Intracellular Drug Accumulation by Induction of the ABCG2 (BCRP) and ABCB1 (MDR1) Drug Transport P

Burger H, van Tol H, Brok M, Wiemer EA, de Bruijn EA, Guetens G, de Boeck G, Sparreboom A, Verweij J, Nooter K.
Cancer Biol Ther. 2005 Jul 9;4(7) [Epub ahead of print]
PMID: 15970668
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Population pharmacokinetics of imatinib mesylate in patients with chronic-phase chronic myeloid leukaemia: results of a phase III study

Schmidli H, Peng B, Riviere GJ, Capdeville R, Hensley M, Gathmann I, Bolton AE, Racine-Poon A.
Br J Clin Pharmacol. 2005 Jul;60(1):35-44.
PMID: 15963092
This study investigated rate of clearance of imatinib from the blood in CML patients (not GIST patients) but the results may have some application to GIST patients.
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Is imatinib justified as an adjuvant chemotherapy for patients with recurrent gastrointestinal stromal tumors?

Lai IR, Hu RH, Chang KJ.
Hepatogastroenterology. 2005 May-Jun;52(63):826-8.
PMID: 15966213
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Evaluation of Ki-67 and p53 expression in primary and repeated liver metastases of GISTs

Gunji Y, Nikaidou T, Okazumi S, Matsubara H, Shimada H, Nabeya Y, Aoki T, Makino H, Miyazaki S, Ochiai T.
Hepatogastroenterology. 2005 May-Jun;52(63):829-32.
PMID: 15966214
Entrez PubMed

Telomerase activity as prognostic factor in gastrointestinal stromal tumors of the stomach.

Kawai J, Kodera Y, Fujiwara M, Kasai Y, Nagasaka T, Koike M, Hibi K, Ito K, Akiyama S, Nakao A.
Hepatogastroenterology. 2005 May-Jun;52(63):959-64.
PMID: 15966241
Entrez PubMed

MR features of gastrointestinal stromal tumors

Caramella T, Schmidt S, Chevallier P, Saint Paul M, Bernard JL, Bidoli R, Bruneton JN.
Clin Imaging. 2005 Jul-Aug;29(4):251-4.
PMID: 15967315
Entrez PubMed

Gastrointestinal stromal tumors express ras oncogene: a potential role for diagnosis and treatment

Blair SL, Al-Refaie WB, Wang-Rodriguez J, Behling C, Ali MW, Moossa AR.
Arch Surg. 2005 Jun;140(6):543-7; discussion 547-8.
PMID: 15967901
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[c-kit and PDGFRA mutations in 60 cases of gastrointestinal stromal tumors (GISTs).]

He HY, Xiang YN, Li Y, Zhong HH, Wu BQ, Zheng J.
Beijing Da Xue Xue Bao. 2005 Jun 18;37(3):320-324.
Abstract in English, paper in Chinese.
PMID: 15968329
Entrez PubMed

High-level detection of gene amplification and chromosome aneuploidy in extracted nuclei from paraffin-embedded tissue of human cancer using FISH: a n

Rossi E, Ubiali A, Balzarini P, Cadei M, Alpi F, Grigolatoi PG.
Eur J Histochem. 2005 Jan-Mar;49(1):53-8.
PMID: 15823795
There were some GISTs among the cancer samples used in this methodological cell study.
Entrez PubMed

Hypoxia-inducible factor-1alpha is associated with risk of aggressive behavior and tumor angiogenesis in gastrointestinal stromal tumor.

Chen WT, Huang CJ, Wu MT, Yang SF, Su YC, Chai CY.
Jpn J Clin Oncol. 2005 Apr;35(4):207-13.
PMID: 15845570
Entrez PubMed

[A case of gastrointestinal stromal tumor of the jejunum with hemorrhage which was preoperatively diagnosed by small bowel enema examination]

Sumida Y, Akahoshi K, Matsuzaka H, Kubokawa M, Akiho H, Fujimaru T, Murakami J, Nagaie T, Nakanishi K, Harada N, Nawada H.
Nippon Shokakibyo Gakkai Zasshi. 2005 May;102(5):564-70. Review.
Paper in Japanese.
No abstract available.
PMID: 15920953
Entrez PubMed

Imatinib mesylate (Gleevec) downregulates telomerase activity and inhibits proliferation in telomerase-expressing cell lines

Uziel O, Fenig E, Nordenberg J, Beery E, Reshef H, Sandbank J, Birenbaum M, Bakhanashvili M, Yerushalmi R, Luria D, Lahav M.
Br J Cancer. 2005 May 23;92(10):1881-91.
PMID: 15870711
Entrez PubMed

Imatinib in pregnancy

AlKindi S, Dennison D, Pathare A.
Eur J Haematol. 2005 Jun;74(6):535-7.
No abstract available.
PMID: 15876261
Entrez PubMed

Gastrointestinal stromal tumors metastatic to the ovary: a report of five cases

Irving JA, Lerwill MF, Young RH.
Am J Surg Pathol. 2005 Jul;29(7):920-6.
PMID: 15958857
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Loss of skin pigment caused by imatinib therapy

McPartlin S, Leach M.
Br J Haematol. 2005 May;129(4):448.
no abstract available
PMID: 15877727
Entrez PubMed

Concurrent male gynecomastia and testicular hydrocele after imatinib mesylate treatment of a gastrointestinal stromal tumor.

Kim H, Chang HM, Ryu MH, Kim TW, Sohn HJ, Kim SE, Kang HJ, Park S, Lee JS, Kang YK.
J Korean Med Sci. 2005 Jun;20(3):512-5.
PMID: 15953881
Entrez PubMed

State-of-the art therapy for gastrointestinal stromal tumors

Blanke CD, Corless CL.
Cancer Invest. 2005;23(3):274-80.
PMID: 15945512
Entrez PubMed

Gastrointestinal stromal tumors: Clinical profile, pathogenesis, treatment strategies and prognosis

Nowain A, Bhakta H, Pais S, Kanel G, Verma S.
J Gastroenterol Hepatol. 2005 Jun;20(6):818-24.
PMID: 15946127
Entrez PubMed

Imatinib resistance in gastrointestinal stromal tumors

Chen LL, Sabripour M, Andtbacka RH, Patel SR, Feig BW, Macapinlac HA, Choi H, Wu EF, Frazier ML, Benjamin RS.
Curr Oncol Rep. 2005 Jul;7(4):293-9.
PMID: 15946589
Entrez PubMed

New drug developments for patients with metastatic soft tissue sarcoma

Hartmann JT, Patel S.
Curr Oncol Rep. 2005 Jul;7(4):300-6.
PMID: 15946590
Entrez PubMed

Critical issues in response evaluation on computed tomography: lessons from the gastrointestinal stromal tumor model

Choi H.
Curr Oncol Rep. 2005 Jul;7(4):307-11.
PMID: 15946591
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Imaging and response in soft tissue sarcomas

Schuetze SM.
Hematol Oncol Clin North Am. 2005 Jun;19(3):471-87.
PMID: 15939192
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Overexpression of carbonic anhydrase-related protein XI promotes proliferation and invasion of gastrointestinal stromal tumors

Morimoto K, Nishimori I, Takeuchi T, Kohsaki T, Okamoto N, Taguchi T, Yunoki S, Watanabe R, Ohtsuki Y, Onishi S.
Virchows Arch. 2005 Jun 8; [Epub ahead of print]
PMID: 15942747
Entrez PubMed

Gastrointestinal stromal tumors

von Mehren M, Watson JC.
Hematol Oncol Clin North Am. 2005 Jun;19(3):547-64.
PMID: 15939196
Entrez PubMed

Recent studies in novel therapy for metastatic sarcomas

Steinert DM, Patel SR.
Hematol Oncol Clin North Am. 2005 Jun;19(3):573-90.
PMID: 15939198
This paper may not discuss GIST but it does discuss relevant drugs including imatinib and SU11248.
Entrez PubMed

A study of histopathological assessment criteria for assessing malignancy of gastrointestinal stromal tumor, from a clinical standpoint

Yokoi K, Tanaka N, Shoji K, Ishikawa N, Seya T, Horiba K, Kanazawa Y, Yamashita K, Ohaki Y, Tajiri T.
J Gastroenterol. 2005 May;40(5):467-73.
PMID: 15942711
Entrez PubMed

[Anticancer drugs and ABC transporters]

Oka M, Fukuda M, Soda H.
Gan To Kagaku Ryoho. 2005 May;32(5):585-92. Review.
paper in Japanese, abstract in English
PMID: 15918555
Entrez PubMed

Differential expression of connexin 43 in gastrointestinal stromal tumours of gastric and small intestinal origin

Nishitani A, Hirota S, Nishida T, Isozaki K, Hashimoto K, Nakagomi N, Matsuda H.
J Pathol. 2005 Aug;206(4):377-82.
PMID: 15938003
Entrez PubMed

Analysis of KIT mutations in sporadic and familial gastrointestinal stromal tumors: therapeutic implications through protein modeling

Tarn C, Merkel E, Canutescu AA, Shen W, Skorobogatko Y, Heslin MJ, Eisenberg B, Birbe R, Patchefsky A, Dunbrack R, Arnoletti JP, von Mehren M, Godwin AK.
Clin Cancer Res. 2005 May 15;11(10):3668-77.
PMID: 15897563
Entrez PubMed

Gastrointestinal stromal tumors: pathogenesis and current treatment

Arru JM, Richardson JD.
J Ky Med Assoc. 2005 May;103(5):211-5.
PMID: 15918651
Entrez PubMed

Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation.

Antonescu CR, Besmer P, Guo T, Arkun K, Hom G, Koryotowski B, Leversha MA, Jeffrey PD, Desantis D, Singer S, Brennan MF, Maki RG, Dematteo RP.
Clin Cancer Res. 2005 Jun 1;11(11):4182-90.
PMID: 15930355
Entrez PubMed

Multiple gastrointestinal stromal tumors in type I neurofibromatosis: a pathologic and molecular study

Yantiss RK, Rosenberg AE, Sarran L, Besmer P, Antonescu CR.
Mod Pathol. 2005 Apr;18(4):475-84.
PMID: 15540118
Entrez PubMed

PDGFRA Mutations In Gastrointestinal Stromal Tumors: Frequency, Spectrum and In Vitro Sensitivity To Imatinib.

Corless CL, Schroeder A, Griffith D, Town A, McGreevey L, Harrell P, Shiraga S, Bainbridge T, Morich J, Heinrich MC.
J Clin Oncol. 2005; 23(23):5357-64
PMID: 159283
Entrez PubMed

9p21 locus analysis in high-risk gastrointestinal stromal tumors characterized for c-kit and platelet-derived growth factor receptor alpha gene altera

Perrone F, Tamborini E, Dagrada GP, Colombo F, Bonadiman L, Albertini V, Lagonigro MS, Gabanti E, Caramuta S, Greco A, Torre GD, Gronchi A, Pierotti MA, Pilotti S.
Cancer. 2005; 104(1):159-69
PMID: 15929122
Entrez PubMed

Elimination of imatinib mesylate and its metabolite N-desmethyl-imatinib.

Bornhauser M, Pursche S, Bonin M, Freiberg-Richter J, Jenke A, Illmer T, Ehninger G, Schleyer E.
J Clin Oncol. 2005 Jun 1;23(16):3855-6.
PMID: 15923584
no abstract available
Entrez PubMed

Gastrointestinal stromal tumors: pathogenesis and current treatment.

Arru JM, Richardson JD.
J Ky Med Assoc. 2005 May;103(5):211-5.
PMID: 15918651
Entrez PubMed

Surgery Including Liver Resection for Metastatic Gastrointestinal Stromal Tumors or Gastrointestinal Leiomyosarcomas.

Nunobe S, Sano T, Shimada K, Sakamoto Y, Kosuge T.
Jpn J Clin Oncol. 2005 May 31; [Epub ahead of print]
PMID: 15928191
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