PubMed search for free-access GIST papers

By clicking the link below you will access a search generated directly in PubMed for all free-access papers on GIST.
Entrez PubMed

Gastrointestinal stromal tumors: radiologic features with pathologic correlation

Levy AD, Remotti HE, Thompson WM, Sobin LH, Miettinen M
Radiographics 2003; 23:283-304.
This paper has excellent CT scan images of GISTs.
PMID 12640147
Entrez PubMed

A quest for therapeutic antigens in bone and soft tissue sarcoma

Satoshi Kawaguchi , Takuro Wada , Tomohide Tsukahara , Kazunori Ida , Toshihiko Torigoe , Noriyuki Sato and Toshihiko Yamashita
Journal of Translational Medicine | Abstract | 1479-5876-3-31
free access online
Journal of Translational Medicine

Fighting cancer throuh the study of sarcomas

Matushansky I , Maki RG
American Scientist 2005 Sept.-Oct; 93:414-421
free access via the website of the Sarcoma Foundation of America

Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread

Burkill GJ, Badran M, Al-Muderis O, Meirion Thomas J, Judson IR, Fisher C, Moskovic EC.
Radiology. 2003 Feb;226(2):527-32.
PMID: 12563150
free access in PubMed
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Gastric stromal tumor

Ovali GY, Tarhan S, Serter S, Pabuscu Y.
Diagnostic and Interventional Radiology. 2005 Jun;11(2):102-4.
PMID: 15957097
free access through PubMed
Entrez PubMed

Diagnosis and management of gastrointestinal sromal tumours

Ray-Coquard I, Blay J-Y
European Pharmacotherapy 2005, pages 2-7.
This is an online pubication from TouchBriefings.
free access pdf viewable using free Adobe reader software
Touchbriefings

Gastrointestinal Stromal Tumors - Leiomyoma/Leiomyosarcoma :

free-access article by Vu Nguyen, MD
eMedicine

Gastrointestinal stromal tumours

Landuyt B, van Oosterom AT
European Pharmacotherapy 2005, pages 2-4.
This is an electronic publication from TouchBriefings.
It is a pdf file viewable with free Adobe reader software.
TouchBriefings

Pleomorphic characteristics of a germ-line KIT mutation in a large kindred with gastrointestinal stromal tumors, hyperpigmentation, and dysphagia

Robson ME, Glogowski E, Sommer G, Antonescu CR, Nafa K, Maki RG, Ellis N, Besmer P, Brennan M, Offit K.
Clin Cancer Res. 2004 Feb 15;10(4):1250-4.
PMID: 14977822
free access in PubMed
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Gene expression in gastrointestinal stromal tumors is distinguished by KIT genotype and anatomic site

Antonescu CR, Viale A, Sarran L, Tschernyavsky SJ, Gonen M, Segal NH, Maki RG, Socci ND, DeMatteo RP, Besmer P.
Clin Cancer Res. 2004 May 15;10(10):3282-90.
PMID: 15161681
free access in PubMed
Entrez PubMed

Prognostic significance of c-kit mutation in localized gastrointestinal stromal tumors

Kim TW, Lee H, Kang YK, Choe MS, Ryu MH, Chang HM, Kim JS, Yook JH, Kim BS, Lee JS.
Clin Cancer Res. 2004 May 1;10(9):3076-81.
PMID: 15131046
free access in PubMed
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Imaging gastrointestsinal stromal tumors

Hersh MR, Choi J, Garrett C, Clark R.
Cancer Control. 2005 Apr;12(2):111-115.
PMID 15855894
Free access in PubMed
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Perforation of metastatic melanoma to the small bowel with simultaneous gastrointestinal stromal tumor.

Brummel N, Awad Z, Frazier S, Liu J, Rangnekar N.
World J Gastroenterol. 2005 May 7;11(17):2687-9.
PMID 15849837
Free access in PubMed.
Entrez PubMed

Gastrointestinal stromal tumors: a clinicopathologic and immunohistochemical study of 136 cases.

Orosz Z, Tornoczky T, Sapi Z.
Pathol Oncol Res. 2005;11(1):11-21. Epub 2005 Mar 31.
PMID 15800677
free access in PubMed
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Malignant Gastrointestinal Stromal Tumor of the Small Intestine Complicated with Pulmonary Tuberculosis during Treatment with Imatinib Mesylate.

Takashima M, Igaki N, Matsuda T, Ohyama M, Kanda S, Tamada F, Goto T.
Internal Medicine (Tokyo) 2005 Feb;44(2):114-9.
PMID: 15750270
free access in PubMed
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Spontaneous rupture of giant gastric stromal tumor into gastric lumen

Mehta RM, Sudheer VO, John AK, Nandakumar RR, Dhar PS, Sudhindran S, Balakrishnan V.
World J Surg Oncol. 2005 Feb 15;3(1):11.
PMID: 15713236
free access in PubMed
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Update on the biology and therapy of gastrointestinal stromal tumors

D'Amato, G; Steinert, DM; McAuliffe, JC; Trent, JC
Cancer Control 2005, 12:44-56
free access via Moffitt Cancer Center
Moffitt Cancer Center

Spontaneous rupture of giant gastric stromal tumor into gastric lumen

Mehta RM, Sudheer VO, John AK, Nandakumar RR, Dhar PS, Sudheendran S, Balakrishnan V.
World J Surg Oncol. 2005 Feb 15;3(1):11
PMID 15713236
free access via PubMed
Entrez PubMed

Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours...

Debiec-Rychter M, Dumez H, Judson I, Wasag B, Verweij J, Brown M, Dimitrijevic S, Sciot R, Stul M, Vranck H, Scurr M, Hagemeijer A, van Glabbeke M, van Oosterom AT; EORTC Soft Tissue and Bone Sarcoma Group.
European Journal of Cancer 2004 March;40(5):689-95.
PMID: 15010069
free access via Novartis
Novartis

NCCN Soft Tissue Sarcoma Clinical Practice in Oncology Guidelines version 1.2005

This flow-chart guideline from the National Comprehensive Cancer Network deals with GIST as well as other sarcomas. It is a 49-page Adobe pdf document. For GIST, see especially the flow charts on pages 15-20 and the text on pages 37-39.
Free access via National Comprehensive Cancer Network website.
You must go through a series of steps at the NCCN website to access this document.
First link to NCCN
NCCN
Then click "NCCN Clinical Practice Guidelines in Oncology."
Then click "NCCN Complete Library of Clinical Practice Guidelines Online."
Scroll to the bottom of the "agreement" page and click "I agree."
On the next page scrool down to Cancer by Site and click "Soft Tissue Sarcoma" in the right-hand column.
This will begin downloading the Adobe pdf document for you to view or print.
If you get lost in those steps, here is a direct link.
Soft Tissue Sarcoma Guidelines v1.2005

KIT and Platelet-Derived Growth Factor Receptor Alpha Tyrosine Kinase Gene Mutations and KIT Amplifications in Human Solid Tumors

Sihto H, Sarlomo-Rikala M, Tynninen O, Tanner M, Andersson LC, Franssila K, Nupponen NN, Joensuu H.
J Clin Oncol. 2005 Jan 1;23(1):49-57.
PMID: 15545668
free access via publisher
Journal of Clinical Oncology

Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours

Chen H, Hirota S, Isozaki K, Sun H, Ohashi A, Kinoshita K, O'Brien P, Kapusta L, Dardick I, Obayashi T, Okazaki T, Shinomura Y, Matsuzawa Y, Kitamura Y
Gut 2002; 51:793-796
free access from publisher
Gut

Molecular targets for tumour progression in gastrointestinal stromal tumours

Koon et al
Gut 2003; 53(2):235-2xx.
Gut

A gastrointestinal stromal tumor (GIST) masquerading as an ovarian mass

Carlomagno G, Beneduce P.
World J Surg Oncol. 2004 May 13;2(1):15.
PMID: 15142276
free access in PubMed
Entrez PubMed

Cystic changes in intraabdominal extrahepatic metastases from gastrointestinal stromal tumors treated with imatinib

Kim HC, Lee JM, Choi SH, Han H, Kim SS, Lee SH, Han JK, Choi BI.
Korean J Radiol. 2004 Jul-Sep;5(3):157-63.
PMID: 15467412
free access in PubMed
Entrez PubMed

Malignant gastrointestinal stromal tumor of the gallbladder

Park JK, Choi SH, Lee S, Min KO, Yun SS, Jeon HM.
J Korean Med Sci. 2004 Oct;19(5):763-7.
PMID: 15483360
free access in PubMed
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An unusual case of gastric heterotopic pancreas

Rubbia-Brandt L, Huber O, Hadengue A, Frossard JL.
JOP. 2004 Nov 10;5(6):484-7.
PMID 15536286
This paper describes differential diagnosis in one case, which was suspected to be GIST but turned out not to be.
free access in PubMed
Entrez PubMed

American Cancer Society: Detailed Guide: Gastrointestinal Stromal Tumors

This website has summary information about GIST.
ACS :: Detailed Guide: GIST

Heinrich and Corless Laboratories Publications

Numerous excellent papers are available for free download at the website of these GIST researchers. Once you have linked, click icon for desired publication year (2004, etc.) to see the papers available.
Heinrich and Corless Laboratories

Inhibitory effect of imatinib on normal progenitor cells in vitro

Bartolovic K, Balabanov S, Hartmann U, Komor M, Boehmler AM, Buhring HJ, Mohle R, Hoelzer D, Kanz L, Hofmann WK, Brummendorf TH.
Blood. 2004 Jan 15;103(2):523-9. Epub 2003 Sep 11.
PMID: 12969987
free access via PubMed
Entrez PubMed

Fatal hepatic necrosis following imatinib mesylate therapy

Lin NU, Sarantopoulos S, Stone JR, Galinsky I, Stone RM, Deangelo DJ, Soiffer RJ.
Blood. 2003 Nov 1;102(9):3455-6.
PMID: 14568907
free access via PubMed
Entrez PubMed

KIT activation is a ubiquitous feature of gastrointestinal stromal tumors

Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, Hibbard MK, Chen CJ, Xiao S, Tuveson DA, Demetri GD, Fletcher CD, Fletcher JA.
Cancer Res. 2001 Nov 15;61(22):8118-21.
PMID: 11719439
free access via PubMed
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Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile

Allander SV, Nupponen NN, Ringner M, Hostetter G, Maher GW, Goldberger N, Chen Y, Carpten J, Elkahloun AG, Meltzer PS.
Cancer Res. 2001 Dec 15;61(24):8624-8.
PMID: 11751374
free access via PubMed
Entrez PubMed

Response markers and the molecular mechanisms of action of Gleevec in gastrointestinal stromal tumors

Frolov A, Chahwan S, Ochs M, Arnoletti JP, Pan ZZ, Favorova O, Fletcher J, von Mehren M, Eisenberg B, Godwin AK.
Mol Cancer Ther. 2003 Aug;2(8):699-709.
PMID: 12939459
free access via PubMed
Entrez PubMed

Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 GISTs

Antonescu CR, Sommer G, Sarran L, Tschernyavsky SJ, Riedel E, Woodruff JM, Robson M, Maki R, Brennan MF, Ladanyi M, DeMatteo RP, Besmer P.
Clin Cancer Res. 2003 Aug 15;9(9):3329-37.
This paper describes exon 9 mutations in GIST, which are less likely to respond to Gleevec.
free access via PubMed
Entrez PubMed

Free-access papers in Korean

These papers are published in Korean.
They are free-access in PubMed.

1: Kang YK.
[Prediction of malignant potential of gastrointestinal stromal tumors]
Korean J Gastroenterol. 2004 Jun;43(6):380-2. Korean. No abstract available.
PMID: 15220557 [PubMed - in process]

2: Kim MK, Lee JK, Park ET, Lee SH, Seol SY, Chung JM, Kang MS, Yoon HK.
[Gastrointestinal stromal tumors: clinical, pathologic features and
effectiveness of new diagnostic criteria]
Korean J Gastroenterol. 2004 Jun;43(6):341-8. Korean.
PMID: 15220551 [PubMed - in process]

3: Lee EJ, Lee OJ, Kim TH, Jung WT.
[A clinical and immunohistochemical study on gastrointestinal stromal tumor]
Korean J Gastroenterol. 2003 Sep;42(3):204-11. Korean.
PMID: 14532742 [PubMed - indexed for MEDLINE]

4: Kim JP, Han DS, Lee HL, Kim JB, Park JY, Eun CS, Lee OY, Sohn JH, Choi HS,
Hahm JS.
[Clinical features of obscure-overt gastrointestinal bleeding]
Korean J Gastroenterol. 2003 Jul;42(1):27-34. Korean.
PMID: 14532728 [PubMed - indexed for MEDLINE]

Entrez PubMed

Clinical manifestations and prognostic factors in patients with gastrointestinal stromal tumors

Lin SC, Huang MJ, Zeng CY, Wang TI, Liu ZL, Shiay RK.
World J Gastroenterol. 2003 Dec;9(12):2809-12.
PMID 14669339
free access in PubMed
Entrez PubMed

Frequent occurrence of low grade cases among metastatic gastrointestinal stromal tumours --

Tornoczky et al.
Journal of Clinical Pathology 2003, 56 (5): 363-367.
Journal of Clinical Pathology

The histopathological differential diagnosis of gastrointestinal stromal tumours

van Roggen et al.
Journal of Clinical Pathology 2001, 54 (2): 96-103.
Journal of Clinical Pathology

Novel Kinase Inhibitors for the Treatment of Imatinib Mesylate–Resistant Gastrointestinal Stromal Tumors

Michael C. Heinrich
This is a nice review from Physicians' Education Resource newsletters.
PERLP Publications

GIST prognosis based on histology

William Check, September 2004 issue of CAP Today
This news story in a publication of the College of American Pathologists is an interview with Henry Appelman, a pathologist who believes that differences in cell appearances of GISTs provide additinal information beyond that indicated by mitotic counts.
College of American Pathologists

Antibodies and kits for KIT

William Check, September 2004 issue of CAP Today
This news story in a publication of the College of American Pathologists discusses differences in pathology stains for epithelioid and spindle cell variants of GIST.
College of American Pathologists

GI stromal tumors: a model for what's coming

William Check, September 2004 issue of CAP Today
This news story in a publication of the College of American Pathologists includes interviews with top pathologists discussing GIST diagnosis.
College of American Pathologists

High efficacy of imatinib for recurrent gastrointestinal stromal tumor in the jejunum: a case report

Kimiyoshi Yokoi, Noritake Tanaka, Shoji Kyouno, Noriyuki Ishikawa, Tomoko Seya, Takashi Shirakawa, Yoshiyuki Takahashi, Yoshiharu Ohaki, Kiyohiko Yamashita and Takashi Tajiri
Journal of Nippon Medical School 2004 71: 114-119.
PMID 15260086
free access via journal
J Nippon Med Sch

Tyrosine kinase inhibitor as a therapeutic drug for chronic myelogenous leukemia

Nakajima M, Toga W.
Nippon Yakurigaku Zasshi. 2003 Dec;122(6):482-90. Review.
PMID: 14639002
free access via PubMed link to publisher
Entrez PubMed

The GIST of targeted cancer therapy: a tumor (gastronitestinal stromal tumor), a mutated gene (c-kit, and a molecular inhibitor (STI571)

Ronald P. DeMatteo
Annals of Surgical Oncology 2002, 9: 831-839.
PMID 12417503
This is a comprehensive review paper.
Entrez PubMed

Upper gastrointestinal hemorrhage due to duodenal stromal tumor

Parreira JG, de Freitas W, Rasslan S.
Arq Gastroenterol. 2003 Jul-Sep;40(3):188-91.
PMID: 15029396
This paper describes bleeding into the GI tract from GIST. This is one of the common presenting symptoms of GIST but is seldom described in detail.
free access via PubMed
Entrez PubMed

Giant malignant gastrointestinal stromal tumors: Recurrence and effects of treatment with STI-571

Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB.
World J Gastroenterol. 2005 Jan 14;11(2):260-3.
PMID: 15633227
free access via PubMed
Entrez PubMed

DNA ploidy and c-Kit mutation in gastrointestinal stromal tumors

Lee JH, Zhang X, Jung WY, Chae YS, Park JJ, Kim I.
World J Gastroenterol. 2004 Dec 1;10(23):3475-9.
PMID: 15526368
free access via PubMed
Entrez PubMed

Angiographic findings of gastrointestinal stromal tumor

Fang SH, Dong DJ, Zhang SZ, Jin M.
World J Gastroenterol. 2004 Oct 1;10(19):2905-7.
PMID: 15334698
free access via PubMed
Entrez PubMed

Gastrointestinal stromal tumor: Computed tomographic features

Lee CM, Chen HC, Leung TK, Chen YY.
World J Gastroenterol. 2004 Aug 15;10(16):2417-8.
PMID: 15285033
free access via PubMed
Entrez PubMed

Inflammatory pseudotumor of the liver in association with a gastrointestinal stromal tumor: a case report

Lo OS, Poon RT, Lam CM, Fan ST.
World J Gastroenterol. 2004 Jun 15;10(12):1841-3.
PMID: 15188521
free access in PubMed
Entrez PubMed

Rediscovering GIST: differential diagnosis of GIST in the era of molecularly targeted therapy

This booklet from Novartis (2002) is in Adobe pdf format and can be viewed or printed with Adobe reader software.
Glivec

Segmental resection of the third portion of the duodenum for a gastrointestinal stromal tumor: a case report

Sakamoto Y, Yamamoto J, Takahashi H, Kokudo N, Yamaguchi T, Muto T, Makuuchi M.
Jpn J Clin Oncol. 2003 Jul;33(7):364-6.
PMID: 12949065
free access via PubMed link to publisher jjco.oupjournals.org
Entrez PubMed

Best cases from the AFIP: gastrointestinal stromal tumors. Armed Forces Institute of Pathology

Sharp RM, Ansel HJ, Keel SB.
Radiographics. 2001 Nov-Dec;21(6):1557-60. No abstract available.
PMID: 11706225
free access via PubMed link to publisher
Entrez PubMed

Malignant gastrointestinal stromal tumor of the ampulla of Vater: a case report

Korean J Gastroenterol. 2004 Jan;43(1):66-70.
Kim SH, Kim JH, Baik GH, Baek I, Hahn T, Oh SO, Kim JB, Park SH, Chang WK, Kim DJ, Park CK, Park HR.
PMID 14745256
free access via PubMed link to publisher
Entrez PubMed

Cerebral relapse of metastatic gastrointestinal stromal tumor during treatment with imatinib mesylate: case report

Hughes B, Yip D, Goldstein D, Waring P, Beshay V, Chong G.
BMC Cancer 2004, 4:74.
Free access in PubMed
Entrez PubMed

Gastrointestinal Stromal Tumors and Leiomyosarcoma of the Abdomen and Retroperitoneum: A Clinical Comparison

Bryan M. Clary, Ronald P. DeMatteo, Jonathan J. Lewis, Denis Leung, and Murray F. Brennan
Annals of Surgical Oncology Apr 1 2001: 290-299
This paper compares series of GIST and LMS tumors and surgical outcomes in the pre-Gleevec era.
Free access via Society of Surgical Oncology.
Annals of Surgical Oncology

Malignant Gastrointestinal Stromal Tumors of the Small Intestine: A Review of 50 Cases From a Prospective Database

Jacqueline A. Crosby, Charles N. Catton, Aileen Davis, Jean Couture, Brian O’Sullivan, Rita Kandel, and Carol J. Swallow
Annals of Surgical Oncology Jan 1 2001: 50-59
This paper describes risk of recurrence of small intestine GISTs after surgery without Gleevec.
Free access via Society of Surgical Oncology.
Annals of Surgical Oncology

GIST Clinical Monograph

This 2002 booklet from Novartis presents summary information about GIST and its treatment using Gleevec (Glivec).
You can view or print it using Adobe Acrobat reader.
Novartis

STI571: A Paradigm of New Agents for Cancer Therapeutics

MJ Mauro, M O’Dwyer, MC Heinrich, BJ Druker
Journal of Clinical Oncology 2002, 20: 325-334
free access at publisher
Journal of Clinical Oncology

High Prognostic Value of p16INK4 Alterations in Gastrointestinal Stromal Tumors

R Schneider-Stock, C Boltze, J Lasota, M Miettinen, B Peters, M Pross, A Roessner, T Günther
Journal of Clinical Oncology 2003 21: 1688-1697.
free access via publisher
Journal of Clinical Oncology

Gastrointestinal stromal tumors: current diagnosis, biologic behavior, and management

I. Pidhorecky, R. T. Cheney, W. G. Kraybill, and J. F. Gibbs
Annals of Surgical Oncology Oct 1 2000: 705-712
This paper deals with risk of GIST recurrence post-surgery during the time period before availability of Gleevec therapy. This applies to patients today who do not use Gleevec after surgery.
Free access via the Society of Surgical Oncology.
Annals of Surgical Oncology

KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size.

Corless CL, McGreevey L, Haley A, Town A, Heinrich MC
Am J Pathol. 2002 May;160(5):1567-72.
PMID 12000708
Entrez PubMed

DNA sequence copy number changes in gastrointestinal stromal tumors: tumor progression and prognostic significance

El-Rifai W, Sarlomo-Rikala M, Andersson LC, Knuutila S, Miettinen M.
Cancer Res. 2000 Jul 15;60(14):3899-903.
PMID: 10919666
free access via PubMed
Entrez PubMed

Mutations in exons 9 and 13 of KIT gene are rare events in gastrointestinal stromal tumors. A study of 200 cases.

Lasota J, Wozniak A, Sarlomo-Rikala M, Rys J, Kordek R, Nassar A, Sobin LH, Miettinen M.
Am J Pathol. 2000 Oct;157(4):1091-5.
PMID 11021812
free access in PubMed
Entrez PubMed

Gastrointestinal stromal tumors (GIST): A model for molecule-based diagnosis and treatment of solid tumors

This review article is free-access.

Kitamura Y, Hirota S, Nishida T
Cancer Science 2003, 94: 315-320
http://www.jca.gr.jp/cs/94/4/315.pdf

The first GIST patient treated with Gleevec

Free full text available via NEJM: click on icon once you are in PubMed.

Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor.
Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, Silberman S, Capdeville R, Dimitrijevic S, Druker B, Demetri GD
N Engl J Med. 2001 Apr 5;344(14):1052-6.
PMID: 11287975
Entrez PubMed

Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable GIST

Dagher R, Cohen M, Williams G, Rothmann M, Gobburu J, Robbie G, Rahman A, Chen G, Staten A, Griebel D, Pazdur R.
Clin Cancer Res. 2002 Oct;8(10):3034-8.
PMID: 12374669
This is the FDA approval summary for Gleevec in metastatic/unresectable GIST.
free full-text access in PubMed.
Entrez PubMed

Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors

Taniguchi M, Nishida T, Hirota S, Isozaki K, Ito T, Nomura T, Matsuda H, Kitamura Y.
Cancer Res. 1999 Sep 1;59(17):4297-300.
PMID: 10485475
free access via PubMed
Entrez PubMed

Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and not .. leiomyomas or leiomyosarcomas

Lasota J, Jasinski M, Sarlomo-Rikala M, Miettinen M.
Am J Pathol. 1999 Jan;154(1):53-60.
PMID 9916918
free access in PubMed
Entrez PubMed