Monday, March 14, 2005

Prevention of Cancer Through Lifestyle Changes

Barnard RJ
Evidence-based Complementary and Alternative Medicine 2005; 1(3):233-2xx.
free access via publisher
Evidence-based Complementary and Alternative Medicine

Monday, February 21, 2005

Emerging Concepts in Nutrigenomics: A Preview of What Is to Come

Gail P.A. Kauwell
Nutrition in Clinical Practice 2005; 20(1):75
This detailed article discusses how what we eat can interact with our genetics to influence disease for better or worse.
free access via publisher until 3/1/2005
Nutrition in Clinical Practice

Wednesday, February 09, 2005

Carrot component reduces cancer risk

Saturday, January 29, 2005

Experimental Studies Defining omega-3 Fatty Acid Antiinflammatory Mechanisms and Abrogation of Tumor-Related Syndromes

Babcock TA, Dekoj T, Espat NJ
Nutrition in Clinical Practice 2005; 20 (1): 62-74
This paper summarizes anti-cancer effects of omega-3 fatty acids.
free access only until 2/28/2005
Nutrition in Clinical Practice

Natural Health Product Interactions with Medication

Boullata J
Nutrition in Clinical Practice 2005; 20 (1):33-51
This paper describes potential interactions between dietary supplements and medications.
free-access until 2/28/2005
Nutrition in Clinical Practice

Wednesday, January 26, 2005

Dietary Guidelines for Americans 2005

These guidelines from the Dept. of Health and Human Services and the US Dept. of Agriculture apply to all Americans. However, they are remarkably similar to the anti-cancer diet ideas!
Dietary Guidelines for Americans 2005

Tuesday, January 25, 2005

Nutrition and cancer: A review of the evidence for an anti-cancer diet

Michael S. Donaldson
Nutrition Journal 2004, 3:19
Free access! Click link, then select fulltext or pdf from left column.
Nutrition Journal

Thursday, January 20, 2005

Immununutrition for surgery patients (a PubMed compilation)

"Immununutrition" provides nutrients including amino acids arginine and glutamine, omega-3 fatty acids, and ribonucleic acids. There is evidence that surgical patients fare better when immune-enhancing nutrition is provided pre- and post-surgery. This group of papers in PubMed is relevant to this topic. Click the "Entrez PubMed" link to see the list, then click on the tan "pages" icon if you want to read an abstract for a list item.
Entrez PubMed

The January 2005 supplement of JPEN Journal of Enteral and Parenteral Nutrition is focused on this topic. The papers are not yet entered into PubMed. However, you can get free access to all of them until 2/28/2005 through the journal itself, which is hosting a special time-limited free-access trial period. Click the "JPEN" link to view the contents of this issue. You can also search the journal for past papers of interest.
JPEN

Wednesday, January 19, 2005

Overview: Anti-Cancer Diet

NUTRITION INFORMATION FOR CANCER SURVIVORS

The food we eat profoundly affects our bodies' functioning and health because food provides not only energy, but also critical nutrients and chemicals which serve as raw materials for body processes. A healthy diet is especially important for individuals with cancer.

General Cancer Prevention Diet

It is widely agreed that appropriate dietary habits decrease the risk of cancer. The same diet recommended to the general population to prevent cancer is also recommended for cancer patients to follow during and after treatment in order to contribute toward disease control and minimize recurrence. The following basic recommendations are stressed by numerous citations in the bibliography, including American Institute for Cancer Research (2002a, 2002b), Goodman (2001), Keane and Chace (1996), Murray et al (2002), Nixon (2000), and World Cancer Research Fund / American Institute for Cancer Research (1997).

1. Include lots of different fruits and vegetables and whole grains and legumes (beans) in your diet. Eat at least 5 servings of fruits and vegetables per day and 7 servings of whole-grain foods, legumes, and nuts. This single recommendation is the most important for accomplishing two goals. First, it provides vitamins, minerals, and other micronutrients, plus non-nutrients with possible anti-cancer effects such as phytochemicals (flavonoids, isoflavones, lignans, polyphenols, and others). These healthy whole foods include antioxidants which can counteract carcinogenic effects at the cellular level by combatting free radicals. Free radicals are unstable molecules (usually containing oxygen or nitrogen) which can damage normal cells and their DNA through chemical reactions. Antioxidants stabilize these molecules, thereby preventing cell damage; this may slow or prevent the development of cancer. Second, this plant-based diet provides fiber (roughage) for colon health.

2. Limit red meat consumption. Three ounces of red meat per day is the maximum recommended by WCRF/AICR, but other authors recommend eating red meat only occasionally. Choose fish, chicken, legumes, soy-based foods, eggs, and low-fat dairy products as your main protein sources. It is important to get enough protein. Some sources (Deane and Chace, 1996; Martin, 2000) indicate that cancer survivors require greater amounts of protein than typical persons: 1-1.5 grams of dietary protein per kilogram of body weight per day, compared to 0.8-1.0 g/kg/day for the general population.

3. Reduce fat consumption to 20-30% of calorie intake and eat good fats. Avoid fats of animal origin and hydrogenated fats in cooking and in purchased baked products. Avoid polyunsaturated cooking oils such as corn, safflower, and sunflower oils; these contain omega-6 fatty acids. Avoid baked goods and crackers containing trans-fats. Choose olive oil and canola oil (rapeseed oil) for cooking. Omega-3 fatty acids, are healthy and desirable. Omega-3 fatty acids are found in certain fish (such as sardines, salmon, mackerel, albacore tuna), walnuts, and golden flaxseed (which can be ground in a coffee grinder and added to other foods).

4. Restrict intake of salt, including salty and salt-cured foods, table salt, and salt used in cooking.

5. Consume no more than two alcoholic drinks per day for men, one for women.

6. Do not eat charred food. A substance called IQ (which stands for "2-amino-3-methylimidazo[4,5-f] quinolone") has been identified as a carcinogen; it forms when meat or eggs are cooked in direct high heat (NIEHS, 2003). Restrict food grilled in direct flame to occasional consumption, and cook meats using lower-temperature methods rather than high-temperature methods such as broiling. Limit intake of smoked or cured meats (hot dogs, bacon, etc.).

7. Avoid being overweight and exercise on a daily basis.


REFERENCES and BIBLIOGRAPHY


American Institute for Cancer Research (2002a). Dietary Options for Cancer Survivors. Washington, DC: American Institute for Cancer Research.

American Institute for Cancer Research (2002b). Nutrition After Cancer. Washington, DC: American Institute for Cancer Research.

Boik, J. (2001). Natural Compounds in Cancer Therapy. Princeton, MN: Oregon Medical Press.

Brown, J.K et al (2003): Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. CA Cancer Journal for Clinicians 53: 268-91.

Byers, T. (2000): Nutrition and cancer: ten lessons from the 20th century. Nutrition, 16: 561-563.

Eyre, H.J. (2001): Nutritional advice for cancer survivors. CA Cancer Journal for Clinicians 51: 151-2.

Goodman, S. (2001): The role of nutrition. In: Integrated Cancer Care, pp. 108-119. Editor: J. Barraclough. Oxford, UK: Oxford University Press.

Gosslau, A. and Chen, K.Y. (2004): Nutraceuticals, apoptosis, and disease prevention. Nutrition 20: 95-102.

Keane, M. and Chace, D. (1996): What to Eat If You Have Cancer. Lincolnwood, IL: Contemporary Books.

Murray, M., Birdsall, T., Pizzorno, JE, Reilly, P. (2002). How to Prevent and Treat Cancer with Natural Medicine. New York: Riverhead Books.

NIEHS (2003). Report on carcinogens, 10th edition. US Dept of Health and Human Services, Public Health Service, National Toxicology Program. Available online at http://ehp.niehs.nig.gov/rec/toc10.html

World Cancer Research Fund in association with American Institute for Cancer Research (1997). Food, Nutrition, and the Prevention of Cancer: a Global Perspective. London: World Cancer Research Fund.

No-authors-listed (2003): Answers to questions often asked by cancer survivors about nutrition and physical activity. CA Cancer Journal for Clinicians 53: 303-309.

Monday, January 17, 2005

Good Books on Cancer Nutrition

Here are two user-friendly paperback books on eating with cancer.

What to Eat if You Have Cancer: a guide to adding nutritional therapy to your treatment plan
Maureen Keane, MS and Daniella Chace, MS
1996, published by Contemporary Books
ISBN 0-8092-3261-8

How to Prevent and Treat Cancer with Natural Medicine
Michael Murray, ND; Tim Birdsall, ND; Joseph E. Pizzorno, ND;
and Paul Reilly, ND
2002, published by Riverhead Books
ISBN 1-57322-343-3

Sunday, January 16, 2005

Journal of Nutrition Supplement: Free Radicals - the Pros and Cons of Antioxidants

Journal of Nutrition, November 2004 134(11): 3143S-3214S.
Free access to this supplement! (but not the rest of the issue)
This is a large group of extended abstracts (paper summaries).
Click the last item in the issue's Table of Contents to see the Supplement contents, then click the item you want to view.
Journal of Nutrition

Diet and Cancer Prevention: Evidence-based Medicine to Genomic Medicine

Vay Liang W. Go, Debra A. Wong, Yu Wang, Ritva R. Butrum, Helen A. Norman, and LuAnn Wilkerson
Diet and Cancer Prevention: Evidence-based Medicine to Genomic Medicine
J. Nutr. 2004 134: 3513S-3516S
Supplement: Int. Research Conference on Food, Nutrition and Cancer
free access
Journal of Nutrition

Clinical Trials in Cancer Prevention: Current Results and Perspectives for the Future

Peter Greenwald
J. Nutr. 134:3507S-3512S, December 2004
Supplement: International Research Conference on Food, Nutrition, and Cancer
Free access!
Journal of Nutrition

Review of the International Research Conference on Food, Nutrition, and Cancer, 2004

Helen A. Norman, Vay Liang W. Go and Ritva R. Butrum
J. Nutr. 134:3391S-3393S, December 2004
Supplement: International Research Conference on Food, Nutrition, and Cancer
Free access!
Journal of Nutrition

Saturday, January 15, 2005

Office of Dietary Supplements

The ODS, part of the National Institutes of Health, provides information about supplements as well as basic nutrition requirements.
Office of Dietary Supplements - HOME

National Center for Complementary and Alternative Medicine (NCCAM)

Under the "Health Information" section of this site there is data on dietary and herbal supplements that can help you separate potentially useful substances from junk pandered by quacks.
The site also includes other helpful news.
National Center for Complementary and Alternative Medicine (NCCAM)

American Institute for Cancer Research - Diet, Nutrition and Cancer Prevention

The AICR's purpose is to discover links between diet and cancer and to disseminate the information. Their site has LOTS of relevant information for cancer survivors, from theory to recipes.
American Institute for Cancer Research - Diet, Nutrition and Cancer Prevention

American Dietetic Association

This site provides general nutrition information, but not cancer-specific information.
Food & Nutrition Infornation

Friday, January 14, 2005

(n-3) fatty acids and cancer therapy

Hardman WE.
Journal of Nutrition. 2004 Dec;134(12 Suppl):3427S-3430S. Review.
PMID: 15570049
Free full-text access!
This is the newest review of how omega-3 (n-3) fatty acids, for which fish oil is the best source, can down-regulate cancer.
Entrez PubMed

Omega-3 fatty acids to augment cancer therapy

Journal of Nutrition. 2002 Nov;132(11 Suppl):3508S-3512S.
Hardman WE.
PMID: 12421878
free full-text access!
This is a good review article on anti-cancer effects of omega-3 fatty acids (primarily from fish oil).
Entrez PubMed

Role of omega-3 fatty acid supplementation in inflammation and malignancy

Integrative Cancer Therapies. 2004 Jun;3(2):98-111.
Jho DH, Cole SM, Lee EM, Espat NJ.
PMID: 15165497 [PubMed - in process]
This paper summarizes the evidence for how eicosapentaenoic acid (a component of fish oil) can slow the growth of cancer and help cachexia (cancer-related wieght loss and muscle wasting).
Entrez PubMed

Cell signaling pathways altered by natural chemopreventive agents

Sarkar FH, Li Y.
Mutat Res. 2004 Nov 2;555(1-2):53-64. Review.
PMID: 15476851
This paper discusses how food-derived substances can down-regulate cell signalling pathways which have been implicated in GIST, including Akt and MAPK, as well as NFkB.
Entrez PubMed

Role of chemopreventive agents in cancer therapy

Dorai T, Aggarwal BB.
Cancer Lett. 2004 Nov 25;215(2):129-40. Review.
PMID: 15488631
This review discusses using natural food substances to assist pharmaceutical cancer therapies.
Entrez PubMed

Fruits, vegetables and risk of renal cell carcinoma: a prospective study of Swedish women

Rashidkhani B, Lindblad P, Wolk A.
Int J Cancer. 2005 Jan 20;113(3):451-5.
PMID: 15455348
This huge longitudinal study confirms protective effects of eating fruit and vegetables.
Entrez PubMed

Immunonutrition and cancer

Philpott M, Ferguson LR.
Mutat Res. 2004 Jul 13;551(1-2):29-42. Review.
PMID: 15225579
This paper discusses how omega-3 fatty acids, green tea polyphenols, zinc, and probiotics modulate immune responses and can potentially slow cancer growth.
Entrez PubMed

Differential effects of delivery of omega-3 fatty acids to human cancer cells by low-density lipoproteins versus albumin

Edwards IJ, Berquin IM, Sun H, O'flaherty JT, Daniel LW, Thomas MJ, Rudel
LL, Wykle RL, Chen YQ.
Clin Cancer Res. 2004 Dec 15;10(24):8275-83.
PMID: 15623603
This article confirms that delivery of omega-3 fatty acids to tumor cells by low-density lipoproteins regulates genes in the tumor cells to inhibit tumor growth.
Entrez PubMed