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Definition
kinaseA kinase is an enzyme (catalyst) that transfers the terminal phosphate group from ATP to a substrate (phosphorylation). KIT and PDGRFA are both tyrosine kinases.
KIT(Also known as CD117, Stem Cell Factor Receptor, and Steel Ligand Receptor). KIT is a transmembrane glycoprotein from the type III receptor tyrosine kinase family. KIT is the receptor for the growth factor Stem Cell Factor, also known as "steel factor" or "KIT ligand." As a result of interaction with Stem Cell Factor, KIT initiates essential signal transduction pathways that transmit biological signals for cellular proliferation, survival, differentiation, and migration. KIT is expressed on almost all hematopoietic progenitor cells, melanocytes, mast cells, and interstitial cells of Cajal from the digestive tract. Aberrant expression or mutations of the c-kit gene is involved in the pathogenesis of several cancers, including GIST. KIT is structurally similar to the Platelet-Derived Growth Factor receptor (PDGFR).


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