GIST Support International - logo

GIST Support International - Glossary of Terms
GIST Imagery
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z all   


Definition
necrosisThe sudden, "unprogrammed" death of living cells or tissues. Necrosis can be due, for example, to ischemia (lack of blood flow). It may affect groups of cells or part of a structure or an organ. In contrast to apoptosis (controlled "programmed" cell death) necrosis results in cellular materials being "spilled" into the body. When tumors grow large enough to outgrow their blood supply, the central portion of the tumor often becomes necrotic.
neoplasmAny new and abnormal growth (also called tumor); specifically a new growth of tissue in which the growth is uncontrolled and progressive. The word neoplasm is not synonymous with cancer. A neoplasm may be benign or malignant. Malignant neoplasms are distinguished from benign in that the former show a greater degree of anaplasia (a loss of differentiation of cells and of their orientation to one another) and have the properties of invasion and metastasis.
neurofibromaFlesh-colored benign growths of varying sizes and shapes on the skin of persons affected by a deficient neurofromatosis 1 (NF1) gene. There may be fewer than 10 of these growths or they may number in the thousands.
neurofibromatosis 1 (NF1)NF1 is a condition characterized by multiple cafe au lait spots, freckling, neurofibromas of the skin, and Lisch nodules in the iris of the eyes. Less common but potentially more serious manifestations include a variety of tumors. Heterozygous mutations of the NF1 gene are responsible for the vast majority of cases of neurofibromatosis. The NF1 gene encodes the tumor-suppressor protein neurofibromin. GISTs are unusually common in persons with NF1, occurring in 5-25% of affected people; the GISTs are usually located in the small intestine and are usually multiple, but they may not cause any symptoms. A comprehensive discussion of NF1 is provided at this link: linkhere
nuclear atypiaAbnormal appearance of the nucleus of a cell. Cancer cells may display nuclear atypia.


back to top