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SPECIAL LINK to free GIST papers in PubMed
This link connects you to a PubMed search for all free-access papers with a keyword of GIST or gastrointestinal stromal tumor. It yields over 200 papers. Once in PubMed you can click the green icon for a paper to link to the abstract. From the abstract page you can link to the full text.
Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and not .. leiomyomas or leiomyosarcomas
Lasota J, Jasinski M, Sarlomo-Rikala M, Miettinen M. Am J Pathol. 1999 Jan;154(1):53-60. PMID 9916918 free access in PubMed
Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors
Taniguchi M, Nishida T, Hirota S, Isozaki K, Ito T, Nomura T, Matsuda H, Kitamura Y. Cancer Res. 1999 Sep 1;59(17):4297-300. PMID: 10485475 free access via PubMed
Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable GIST
Dagher R, Cohen M, Williams G, Rothmann M, Gobburu J, Robbie G, Rahman A, Chen G, Staten A, Griebel D, Pazdur R. Clin Cancer Res. 2002 Oct;8(10):3034-8. PMID: 12374669 This is the FDA approval summary for Gleevec in metastatic/unresectable GIST. free full-text access in PubMed.
The first GIST patient treated with Gleevec
Free full text available via NEJM: click on icon once you are in PubMed. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, Silberman S, Capdeville R, Dimitrijevic S, Druker B, Demetri GD N Engl J Med. 2001 Apr 5;344(14):1052-6. PMID: 11287975
Gastrointestinal stromal tumors (GIST): A model for molecule-based diagnosis and treatment of solid tumors
This review article is free-access. Kitamura Y, Hirota S, Nishida T Cancer Science 2003, 94: 315-320
Mutations in exons 9 and 13 of KIT gene are rare events in gastrointestinal stromal tumors. A study of 200 cases.
Lasota J, Wozniak A, Sarlomo-Rikala M, Rys J, Kordek R, Nassar A, Sobin LH, Miettinen M. Am J Pathol. 2000 Oct;157(4):1091-5. PMID 11021812 free access in PubMed
DNA sequence copy number changes in gastrointestinal stromal tumors: tumor progression and prognostic significance
El-Rifai W, Sarlomo-Rikala M, Andersson LC, Knuutila S, Miettinen M. Cancer Res. 2000 Jul 15;60(14):3899-903. PMID: 10919666 free access via PubMed
KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size.
Corless CL, McGreevey L, Haley A, Town A, Heinrich MC Am J Pathol. 2002 May;160(5):1567-72. PMID 12000708
Gastrointestinal stromal tumors: current diagnosis, biologic behavior, and management
I. Pidhorecky, R. T. Cheney, W. G. Kraybill, and J. F. Gibbs Annals of Surgical Oncology Oct 1 2000: 705-712 This paper deals with risk of GIST recurrence post-surgery during the time period before availability of Gleevec therapy. This applies to patients today who do not use Gleevec after surgery. Free access via the Society of Surgical Oncology.
High Prognostic Value of p16INK4 Alterations in Gastrointestinal Stromal Tumors
R Schneider-Stock, C Boltze, J Lasota, M Miettinen, B Peters, M Pross, A Roessner, T Günther Journal of Clinical Oncology 2003 21: 1688-1697. free access via publisher
STI571: A Paradigm of New Agents for Cancer Therapeutics
MJ Mauro, M O’Dwyer, MC Heinrich, BJ Druker Journal of Clinical Oncology 2002, 20: 325-334 free access at publisher
GIST Clinical Monograph
This 2002 booklet from Novartis presents summary information about GIST and its treatment using Gleevec (Glivec). You can view or print it using Adobe Acrobat reader.
Malignant Gastrointestinal Stromal Tumors of the Small Intestine: A Review of 50 Cases From a Prospective Database
Jacqueline A. Crosby, Charles N. Catton, Aileen Davis, Jean Couture, Brian O’Sullivan, Rita Kandel, and Carol J. Swallow Annals of Surgical Oncology Jan 1 2001: 50-59 This paper describes risk of recurrence of small intestine GISTs after surgery without Gleevec. Free access via Society of Surgical Oncology.
Gastrointestinal Stromal Tumors and Leiomyosarcoma of the Abdomen and Retroperitoneum: A Clinical Comparison
Bryan M. Clary, Ronald P. DeMatteo, Jonathan J. Lewis, Denis Leung, and Murray F. Brennan Annals of Surgical Oncology Apr 1 2001: 290-299 This paper compares series of GIST and LMS tumors and surgical outcomes in the pre-Gleevec era. Free access via Society of Surgical Oncology.
Cerebral relapse of metastatic gastrointestinal stromal tumor during treatment with imatinib mesylate: case report
Hughes B, Yip D, Goldstein D, Waring P, Beshay V, Chong G. BMC Cancer 2004, 4:74. Free access in PubMed
Malignant gastrointestinal stromal tumor of the ampulla of Vater: a case report
Korean J Gastroenterol. 2004 Jan;43(1):66-70. Kim SH, Kim JH, Baik GH, Baek I, Hahn T, Oh SO, Kim JB, Park SH, Chang WK, Kim DJ, Park CK, Park HR. PMID 14745256 free access via PubMed link to publisher
Best cases from the AFIP: gastrointestinal stromal tumors. Armed Forces Institute of Pathology
Sharp RM, Ansel HJ, Keel SB. Radiographics. 2001 Nov-Dec;21(6):1557-60. No abstract available. PMID: 11706225 free access via PubMed link to publisher
Segmental resection of the third portion of the duodenum for a gastrointestinal stromal tumor: a case report
Sakamoto Y, Yamamoto J, Takahashi H, Kokudo N, Yamaguchi T, Muto T, Makuuchi M. Jpn J Clin Oncol. 2003 Jul;33(7):364-6. PMID: 12949065 free access via PubMed link to publisher
Rediscovering GIST: differential diagnosis of GIST in the era of molecularly targeted therapy
This booklet from Novartis (2002) is in Adobe pdf format and can be viewed or printed with Adobe reader software.
Inflammatory pseudotumor of the liver in association with a gastrointestinal stromal tumor: a case report
Lo OS, Poon RT, Lam CM, Fan ST. World J Gastroenterol. 2004 Jun 15;10(12):1841-3. PMID: 15188521 free access in PubMed
Gastrointestinal stromal tumor: Computed tomographic features
Lee CM, Chen HC, Leung TK, Chen YY. World J Gastroenterol. 2004 Aug 15;10(16):2417-8. PMID: 15285033 free access via PubMed
Angiographic findings of gastrointestinal stromal tumor
Fang SH, Dong DJ, Zhang SZ, Jin M. World J Gastroenterol. 2004 Oct 1;10(19):2905-7. PMID: 15334698 free access via PubMed
DNA ploidy and c-Kit mutation in gastrointestinal stromal tumors
Lee JH, Zhang X, Jung WY, Chae YS, Park JJ, Kim I. World J Gastroenterol. 2004 Dec 1;10(23):3475-9. PMID: 15526368 free access via PubMed
Giant malignant gastrointestinal stromal tumors: Recurrence and effects of treatment with STI-571
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB. World J Gastroenterol. 2005 Jan 14;11(2):260-3. PMID: 15633227 free access via PubMed
Upper gastrointestinal hemorrhage due to duodenal stromal tumor
Parreira JG, de Freitas W, Rasslan S. Arq Gastroenterol. 2003 Jul-Sep;40(3):188-91. PMID: 15029396 This paper describes bleeding into the GI tract from GIST. This is one of the common presenting symptoms of GIST but is seldom described in detail. free access via PubMed
The GIST of targeted cancer therapy: a tumor (gastronitestinal stromal tumor), a mutated gene (c-kit, and a molecular inhibitor (STI571)
Ronald P. DeMatteo Annals of Surgical Oncology 2002, 9: 831-839. PMID 12417503 This is a comprehensive review paper.
Tyrosine kinase inhibitor as a therapeutic drug for chronic myelogenous leukemia
Nakajima M, Toga W. Nippon Yakurigaku Zasshi. 2003 Dec;122(6):482-90. Review. PMID: 14639002 free access via PubMed link to publisher
High efficacy of imatinib for recurrent gastrointestinal stromal tumor in the jejunum: a case report
Kimiyoshi Yokoi, Noritake Tanaka, Shoji Kyouno, Noriyuki Ishikawa, Tomoko Seya, Takashi Shirakawa, Yoshiyuki Takahashi, Yoshiharu Ohaki, Kiyohiko Yamashita and Takashi Tajiri Journal of Nippon Medical School 2004 71: 114-119. PMID 15260086 free access via journal
GI stromal tumors: a model for what's coming
William Check, September 2004 issue of CAP Today This news story in a publication of the College of American Pathologists includes interviews with top pathologists discussing GIST diagnosis.
Antibodies and kits for KIT
William Check, September 2004 issue of CAP Today This news story in a publication of the College of American Pathologists discusses differences in pathology stains for epithelioid and spindle cell variants of GIST.
GIST prognosis based on histology
William Check, September 2004 issue of CAP Today This news story in a publication of the College of American Pathologists is an interview with Henry Appelman, a pathologist who believes that differences in cell appearances of GISTs provide additinal information beyond that indicated by mitotic counts.
Novel Kinase Inhibitors for the Treatment of Imatinib Mesylate–Resistant Gastrointestinal Stromal Tumors
Michael C. Heinrich This is a nice review from Physicians' Education Resource newsletters.
The histopathological differential diagnosis of gastrointestinal stromal tumours
van Roggen et al. Journal of Clinical Pathology 2001, 54 (2): 96-103.
Frequent occurrence of low grade cases among metastatic gastrointestinal stromal tumours
Tornoczky et al. Journal of Clinical Pathology 2003, 56 (5): 363-367.
Clinical manifestations and prognostic factors in patients with gastrointestinal stromal tumors
Lin SC, Huang MJ, Zeng CY, Wang TI, Liu ZL, Shiay RK. World J Gastroenterol. 2003 Dec;9(12):2809-12. PMID 14669339 free access in PubMed
Free-access papers in Korean
These papers are published in Korean. They are free-access in PubMed. 1: Kang YK. [Prediction of malignant potential of gastrointestinal stromal tumors] Korean J Gastroenterol. 2004 Jun;43(6):380-2. Korean. No abstract available. PMID: 15220557 [PubMed - in process] 2: Kim MK, Lee JK, Park ET, Lee SH, Seol SY, Chung JM, Kang MS, Yoon HK. [Gastrointestinal stromal tumors: clinical, pathologic features and effectiveness of new diagnostic criteria] Korean J Gastroenterol. 2004 Jun;43(6):341-8. Korean. PMID: 15220551 [PubMed - in process] 3: Lee EJ, Lee OJ, Kim TH, Jung WT. [A clinical and immunohistochemical study on gastrointestinal stromal tumor] Korean J Gastroenterol. 2003 Sep;42(3):204-11. Korean. PMID: 14532742 [PubMed - indexed for MEDLINE] 4: Kim JP, Han DS, Lee HL, Kim JB, Park JY, Eun CS, Lee OY, Sohn JH, Choi HS, Hahm JS. [Clinical features of obscure-overt gastrointestinal bleeding] Korean J Gastroenterol. 2003 Jul;42(1):27-34. Korean. PMID: 14532728 [PubMed - indexed for MEDLINE]
Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 GISTs
Antonescu CR, Sommer G, Sarran L, Tschernyavsky SJ, Riedel E, Woodruff JM, Robson M, Maki R, Brennan MF, Ladanyi M, DeMatteo RP, Besmer P. Clin Cancer Res. 2003 Aug 15;9(9):3329-37. This paper describes exon 9 mutations in GIST, which are less likely to respond to Gleevec. free access via PubMed
Response markers and the molecular mechanisms of action of Gleevec in gastrointestinal stromal tumors
Frolov A, Chahwan S, Ochs M, Arnoletti JP, Pan ZZ, Favorova O, Fletcher J, von Mehren M, Eisenberg B, Godwin AK. Mol Cancer Ther. 2003 Aug;2(8):699-709. PMID: 12939459 free access via PubMed
Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile
Allander SV, Nupponen NN, Ringner M, Hostetter G, Maher GW, Goldberger N, Chen Y, Carpten J, Elkahloun AG, Meltzer PS. Cancer Res. 2001 Dec 15;61(24):8624-8. PMID: 11751374 free access via PubMed
KIT activation is a ubiquitous feature of gastrointestinal stromal tumors
Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, Hibbard MK, Chen CJ, Xiao S, Tuveson DA, Demetri GD, Fletcher CD, Fletcher JA. Cancer Res. 2001 Nov 15;61(22):8118-21. PMID: 11719439 free access via PubMed
Fatal hepatic necrosis following imatinib mesylate therapy
Lin NU, Sarantopoulos S, Stone JR, Galinsky I, Stone RM, Deangelo DJ, Soiffer RJ. Blood. 2003 Nov 1;102(9):3455-6. PMID: 14568907 free access via PubMed
Inhibitory effect of imatinib on normal progenitor cells in vitro
Bartolovic K, Balabanov S, Hartmann U, Komor M, Boehmler AM, Buhring HJ, Mohle R, Hoelzer D, Kanz L, Hofmann WK, Brummendorf TH. Blood. 2004 Jan 15;103(2):523-9. Epub 2003 Sep 11. PMID: 12969987 free access via PubMed
Heinrich and Corless Laboratories Publications
Numerous excellent papers are available for free download at the website of these GIST researchers. Once you have linked, click icon for desired publication year (2004, etc.) to see the papers available.
American Cancer Society: Detailed Guide: Gastrointestinal Stromal Tumors
This website has summary information about GIST.
An unusual case of gastric heterotopic pancreas
Rubbia-Brandt L, Huber O, Hadengue A, Frossard JL. JOP. 2004 Nov 10;5(6):484-7. PMID 15536286 This paper describes differential diagnosis in one case, which was suspected to be GIST but turned out not to be. free access in PubMed
Malignant gastrointestinal stromal tumor of the gallbladder
Park JK, Choi SH, Lee S, Min KO, Yun SS, Jeon HM. J Korean Med Sci. 2004 Oct;19(5):763-7. PMID: 15483360 free access in PubMed
Cystic changes in intraabdominal extrahepatic metastases from gastrointestinal stromal tumors treated with imatinib
Kim HC, Lee JM, Choi SH, Han H, Kim SS, Lee SH, Han JK, Choi BI. Korean J Radiol. 2004 Jul-Sep;5(3):157-63. PMID: 15467412 free access in PubMed
A gastrointestinal stromal tumor (GIST) masquerading as an ovarian mass
Carlomagno G, Beneduce P. World J Surg Oncol. 2004 May 13;2(1):15. PMID: 15142276 free access in PubMed
Molecular targets for tumour progression in gastrointestinal stromal tumours
Koon et al Gut 2003; 53(2):235-2xx.
Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours
Chen H, Hirota S, Isozaki K, Sun H, Ohashi A, Kinoshita K, O'Brien P, Kapusta L, Dardick I, Obayashi T, Okazaki T, Shinomura Y, Matsuzawa Y, Kitamura Y Gut 2002; 51:793-796 free access from publisher
KIT and Platelet-Derived Growth Factor Receptor Alpha Tyrosine Kinase Gene Mutations and KIT Amplifications in Human Solid Tumors
Sihto H, Sarlomo-Rikala M, Tynninen O, Tanner M, Andersson LC, Franssila K, Nupponen NN, Joensuu H. J Clin Oncol. 2005 Jan 1;23(1):49-57. PMID: 15545668 free access via publisher
NCCN Soft Tissue Sarcoma Clinical Practice in Oncology Guidelines version 1.2005
This flow-chart guideline from the National Comprehensive Cancer Network deals with GIST as well as other sarcomas. It is a 49-page Adobe pdf document. For GIST, see especially the flow charts on pages 15-20 and the text on pages 37-39. Free access via National Comprehensive Cancer Network website.
Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours
Debiec-Rychter M, Dumez H, Judson I, Wasag B, Verweij J, Brown M, Dimitrijevic S, Sciot R, Stul M, Vranck H, Scurr M, Hagemeijer A, van Glabbeke M, van Oosterom AT; EORTC Soft Tissue and Bone Sarcoma Group. European Journal of Cancer 2004 March;40(5):689-95. PMID: 15010069 free access via Novartis
Spontaneous rupture of giant gastric stromal tumor into gastric lumen
Mehta RM, Sudheer VO, John AK, Nandakumar RR, Dhar PS, Sudheendran S, Balakrishnan V. World J Surg Oncol. 2005 Feb 15;3(1):11 PMID 15713236 free access via PubMed
Update on the biology and therapy of gastrointestinal stromal tumors
D'Amato, G; Steinert, DM; McAuliffe, JC; Trent, JC Cancer Control 2005, 12:44-56 free access via Moffitt Cancer Center
Spontaneous rupture of giant gastric stromal tumor into gastric lumen
Mehta RM, Sudheer VO, John AK, Nandakumar RR, Dhar PS, Sudhindran S, Balakrishnan V. World J Surg Oncol. 2005 Feb 15;3(1):11. PMID: 15713236 free access in PubMed
Malignant Gastrointestinal Stromal Tumor of the Small Intestine Complicated with Pulmonary Tuberculosis during Treatment with Imatinib Mesylate.
Takashima M, Igaki N, Matsuda T, Ohyama M, Kanda S, Tamada F, Goto T. Internal Medicine (Tokyo) 2005 Feb;44(2):114-9. PMID: 15750270 free access in PubMed
Gastrointestinal stromal tumors: a clinicopathologic and immunohistochemical study of 136 cases.
Orosz Z, Tornoczky T, Sapi Z. Pathol Oncol Res. 2005;11(1):11-21. Epub 2005 Mar 31. PMID 15800677 free access in PubMed
Perforation of metastatic melanoma to the small bowel with simultaneous gastrointestinal stromal tumor.
Brummel N, Awad Z, Frazier S, Liu J, Rangnekar N. World J Gastroenterol. 2005 May 7;11(17):2687-9. PMID 15849837 Free access in PubMed.
Imaging gastrointestsinal stromal tumors
Hersh MR, Choi J, Garrett C, Clark R. Cancer Control. 2005 Apr;12(2):111-115. PMID 15855894 Free access in PubMed
Prognostic significance of c-kit mutation in localized gastrointestinal stromal tumors
Kim TW, Lee H, Kang YK, Choe MS, Ryu MH, Chang HM, Kim JS, Yook JH, Kim BS, Lee JS. Clin Cancer Res. 2004 May 1;10(9):3076-81. PMID: 15131046 free access in PubMed
Gene expression in gastrointestinal stromal tumors is distinguished by KIT genotype and anatomic site
Antonescu CR, Viale A, Sarran L, Tschernyavsky SJ, Gonen M, Segal NH, Maki RG, Socci ND, DeMatteo RP, Besmer P. Clin Cancer Res. 2004 May 15;10(10):3282-90. PMID: 15161681 free access in PubMed
Pleomorphic characteristics of a germ-line KIT mutation in a large kindred with gastrointestinal stromal tumors, hyperpigmentation, and dysphagia
Robson ME, Glogowski E, Sommer G, Antonescu CR, Nafa K, Maki RG, Ellis N, Besmer P, Brennan M, Offit K. Clin Cancer Res. 2004 Feb 15;10(4):1250-4. PMID: 14977822 free access in PubMed
Gastrointestinal stromal tumours
Landuyt B, van Oosterom AT European Pharmacotherapy 2005, pages 2-4. This is an electronic publication from TouchBriefings. It is a pdf file viewable with free Adobe reader software.
Gastrointestinal Stromal Tumors - Leiomyoma/Leiomyosarcoma :
free-access article by Vu Nguyen, MD
Diagnosis and management of gastrointestinal sromal tumours
Ray-Coquard I, Blay J-Y European Pharmacotherapy 2005, pages 2-7. This is an online pubication from TouchBriefings. free access pdf viewable using free Adobe reader software
Gastric stromal tumor
Ovali GY, Tarhan S, Serter S, Pabuscu Y. Diagnostic and Interventional Radiology. 2005 Jun;11(2):102-4. PMID: 15957097 free access through PubMed
Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread
Burkill GJ, Badran M, Al-Muderis O, Meirion Thomas J, Judson IR, Fisher C, Moskovic EC. Radiology. 2003 Feb;226(2):527-32. PMID: 12563150 free access in PubMed
Fighting cancer through the study of sarcomas
Matushansky I , Maki RG American Scientist 2005 Sept.-Oct; 93:414-421 free access via the website of the Sarcoma Foundation of America
A quest for therapeutic antigens in bone and soft tissue sarcoma
Satoshi Kawaguchi , Takuro Wada , Tomohide Tsukahara , Kazunori Ida , Toshihiko Torigoe , Noriyuki Sato and Toshihiko Yamashita Journal of Translational Medicine | Abstract | 1479-5876-3-31 free access online
A quest for therapeutic antigens in bone and soft tissue sarcoma
Satoshi Kawaguchi , Takuro Wada , Tomohide Tsukahara , Kazunori Ida , Toshihiko Torigoe , Noriyuki Sato and Toshihiko Yamashita Journal of Translational Medicine | Abstract | 1479-5876-3-31 free access online
Gastrointestinal stromal tumors: radiologic features with pathologic correlation
Levy AD, Remotti HE, Thompson WM, Sobin LH, Miettinen M Radiographics 2003; 23:283-304. This paper has excellent CT scan images of GISTs. PMID 12640147

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