GIST Support International - logo

GIST Support International - Webcasts and Slideshows
GIST Imagery

This page provides links to presentations at scientific and medical society meetings about gastrointestinal stromal tumor (GIST cancer), GIST diagnosis, or GIST treatment.  Those designated as webcasts include audio of the speaker, plus visuals of the slides shown by the speaker (almost like being there!) and a few also offer video of the speaker. Those designated as slide shows provide only the visual aids used by the speaker, without any voice.  By studying the slides, you can still get a lot of information, even though it is not explained.

Note that some of the webcasts may not work in browsers other than Internet Explorer.

Some slide shows are actual Microsoft Powerpoint files, and some have been converted to Adobe pdf files.  To view these you can download free readers from Microsoft (for Powerpoint) or from Adobe (for pdf).

Also see the videos from the GIST Summits we sponsor each year!

Unfortunately, ASCO presentations are now not available for pubilc viewing until 3 years after the ASCO meeting.

CTOS presentations after the 2009 meeting are no longer available for public view at all.

Advances in the Management of Gastrointestinal Stromal Tumors
Presenters: Peter Reichardt, MD, PhD; George D. Demetri, MD; Jean-Yves Blay, MD, PhD; Heikki Joensuu, MD, PhD Free access on Medscape after a free registration.
Advances in the Treatment of GIST: From Evidence to Practice
Presenters: George D. Demetri, MD; Ronald DeMatteo, MD free access through Medscape after a free registration
Optimizing the Management of Resectable Gastrointestinal Stromal Tumors
George D. Demetri, MD; Jean-Yves Blay, MD, PhD; Florence Duffaud, MD PhD November 2010. Adjuvant Gleevec is discussed. This is a Medscape CME webcast plus transcript that you can access after a free registration.
ESMO Conference: Sarcoma and GIST, Milan, Italy, March 9-10, 2010
From this single link (above) you can click individual titles (listed below) to view webcasts of all the presentations in the following sessions. Note that the download takes a few minutes.
2. HOW TO CLINICALLY APPROACH GIST
How to diagnose (R. Sciot)
How to predict (M. Debiec Rychter)
How to treat the advanced disease (J. Trent)
How to manage therapy (S. George)
3. HOW TO IMPROVE MOLECULAR BASED TECHNOLOGY IN GIST
Advances in understanding functional imaging (J. Yap)
Advances in non-KIT signalling (C. Antonescu)
Advances in secondary resistance mechanisms (J. Fletcher)
Advances in experimental drugs (G. D. Demetri)
8. HOW WE COULD IMPROVE OUR METHOD IN ASSESSMENT OF TREATMENT ENDPOINTS How to conceive tumor response in sarcomas and GIST (R. Benjamin)
COMPLETE LOSS OF SUCCINATE DEHYDROGENASE B (SDHB) PROTEIN IN PEDIATRIC GASTROINTESTINAL STROMAL TUMORS (GIST)
Authors: K Janeway; B Liegl; V Nose; J L Hornick; J Barretina; P L Dahia; J A Fletcher
Slides from presentation at CTOS meeting, November 2009.
MICROSCOPIC GASTROINTESTINAL STROMAL TUMORS (MICGIST): CLINICOPATHOLOGICAL AND MOLECULAR ANALYSIS OF 85 CASES.
Authors: S Rossi; D Gasparotto; L Toffolatti; C Sartor; G Gallina; A Marzotto; R Talamini; G Mazzoleni; I Bearzi; L Messerini; C Cantaloni; M Barbareschi; R Maestro; A P Dei Tos
Slides from presentation at CTOS meeting, November 2009.
HIGH DENSITY DNA ARRAY ANALYSIS REVEALS DISTINCT GENOMIC PROFILES IN A SUBSET OF GASTROINTESTINAL STROMAL TUMORS
Authors: M G. Belinsky; Y V. Skorobogatko; L Rink; J Pei; K Q. Cai; L A. Vanderveer; D Riddell; E Merkel; C Tarn; B L. Eisenberg; M von Mehren; J R. Testa; A K. Godwin
Slides from presentation at CTOS meeting, November 2009
STEADY-STATE PLASMA IMATINIB LEVELS IN 124 GIST PATIENTS: DISTRIBUTION, DOSE, DOSE ESCALATION, AND RESPONSE
Authors: L K Nolden; L Shum; A Dumont; S Patel; D M Araujo; J A Ludwig; V Ravi; S George; S Vadhan-Raj; R S Benjamin; J C Trent
Slides from presentation at CTOS meeting, Novenber 2009
IMATINIB MESYLATE MODULATES REGULATORS OF TUMOR CELL QUIESCENCE IN GASTROINTESTINAL STROMAL TUMOR CELLS
Authors: J A Parry; M F Brown; D Seneviratne; S Duensing; A Duensing
Slides from presentation at CTOS meeting, November 2009
Discussion - Kinase dependence of GIST: An uncommon tale of oncologic consistency
2009 ASCO Annual Meeting
Robert G. Maki, MD, PhD Discussant
Session: Novel Strategies for More Personalized Management of Sarcoma
In vitro activity of sorafenib against imatinib- and sunitinib-resistant kinase mutations associated with drug-resistant GIST
Meeting: 2009 ASCO Annual Meeting
Presenter: Jonathan A. Fletcher, MD
Session: Novel Strategies for More Personalized Management of Sarcoma (Clinical Science Symposium)
Redefining our Knowledge of GIST: From Old Chromosomes to New Drugs
2009 ASCO Annual Meeting
Charles Blanke, MD
Discussant
Simultaneous gastrointestinal stromal tumor (GIST) and desmoid fibromatosis (DF).
Meeting: 2009 ASCO Annual Meeting
Presenter: Amaury G Dumont, PharmD
Session: Sarcoma (General Poster Session)
Unusual metastatic sites in gastrointestinal stromal tumor (GIST).
Meeting: 2009 ASCO Annual Meeting
Presenter: Rossella Bertulli, MD
Session: Sarcoma (General Poster Session)
Response to sirolimus in combination to tirosine kinase inhibitors (TKI) in three cases of PDGFRA-D842V metastatic gastrointestinal stromal tumor (GIST).
Meeting: 2009 ASCO Annual Meeting
Presenter: Claudio Piovesan, MD
Session: Sarcoma (General Poster Session)
KIT and PDGFRA mutations of gastrointestinal stromal tumor
Meeting: 2009 ASCO Annual Meeting
Presenter: Toshirou Nishida, MD, PhD, FACS
Session: Sarcoma (General Poster Session)
Type of progression in patients treated with imatinib for advanced gastrointestinal stromal tumor (GIST): A study based on the EORTC-ISG-AGITG trial 62005
Meeting: 2009 ASCO Annual Meeting
Presenter: Martine M Van Glabbeke, PhD
Session: Sarcoma (Poster Discussion)
Molecular epidemiology of GISTs: Incidence of PDGFRA and KIT exon 9 mutations in the large French population-based study molecGIST.
Meeting: 2009 ASCO Annual Meeting
Presenter: Jean-François Emile, MD, PhD
Session: Sarcoma (Poster Discussion)
Assessment of the heat shock protein 90 (HSP90) inhibitor IPI504 alone or in combination with the tyrosine kinase inhibitor (TKI) imatinib in mice carrying xenografts of human gastrointestinal stromal tumors (GIST).
Meeting: 2009 ASCO Annual Meeting
Presenter: Patrick Schoffski, MD, MPH
Session: Sarcoma (Poster Discussion)
Correlation of gastrointestinal stromal tumor (GIST) gene expression signatures and response to imatinib mesylate in the Radiation Therapy Oncology Group phase II clinical trial S-0132
Meeting: 2009 ASCO Annual Meeting
Presenter: Lori Rink, PhD
Session: Sarcoma (Poster Discussion)
Myelodysplastic syndromes developing after imatinib therapy for GIST
Meeting: 2009 ASCO Annual Meeting
Presenter: Pietro Spadaro
Session: Sarcoma (Poster Discussion)
Masatinib mesylate in imatinib-naive locally advanced or metastatic gastrointestinal stromal tumor (GIST): Results of the French Sarcoma Group phase II trial. Print this page
Meeting: 2009 ASCO Annual Meeting
Presenter: Axel Le Cesne, MD
Session: Sarcoma (Oral Presentation)
IGF1R Over-expression is Present in a Subset of Wild-type but not Kinase Mutant GI Stromal Tumors
Meeting: 2009 ASCO Annual Meeting
Presenter: Christopher Corless, MD, PhD
Session: Sarcoma (Oral Presentation)
Masatinib mesylate in imatinib-naive locally advanced or metastatic gastrointestinal stromal tumor (GIST): Results of the French Sarcoma Group phase II trial.
Meeting: 2009 ASCO Annual Meeting
Presenter: Axel Le Cesne, MD
Novel Strategies for More Personalized Management of Sarcoma
Presenter: Robert G. Maki, MD, PhD
from the 2009 ASCO annual meeting also accessible:

In vitro activity of sorafenib against imatinib- and sunitinib-resistant kinase mutations associated with drug-resistant GIST
Presenter: Jonathan A. Fletcher, MD

Discussion - Kinase dependence of GIST: An uncommon tale of oncologic consistency
Presenter: Robert G. Maki, MD, PhD
New Therapies for GIST
Presenter: Jonathan Trent, MD.
Video from the GIST Summit, October 2009, at MD Anderson Cancer Center
Adjuvant therapy and surgical management of GIST
Presenter: Peter Pisters, MD FACS
Video from the GIST Summit, October 2009, at MD Anderson Cancer Center
Radiologic imaging: Responding or Not Responding -- Lessons from the GIST Model
Presenter: Haesun Choi, MD
Video from the GIST Summit, October 2009, at MD Anderson Cancer Center
Ask the Expert Session featuring Haesun Choi, MD and Pat Neal, RN
Video from the GIST Summit, October 2009, at MD Anderson Cancer Center
Side effects of Tyrosine Kinase Inhibitors
Presenters: Pat Neal, RN with Ginger Sawyer and Carol Gangstead
Video from the GIST Summit, October 2009, at MD Anderson Cancer Center
The Role of Drug Plasma Level Testing in Metastatic GIST
Presenter: Suzanne George, MD
Video from the GIST Summit, October 2009, at MD Anderson Cancer Center
Ask the Experts session featuring Suzanne George, MD; Laura Nolden, MS; and Tony Conley, MD
Video from the GIST Summit, October 2009, at MD Anderson Cancer Center
Exploring the Role of Adjuvant Therapy in GIST: Are We There Yet?
A 2009 CME presentation on Medscape (which is free access after registration), with presenters Jonathan A. Fletcher, MD; Margaret von Mehren, MD; Ronald P. DeMatteo, MD.
Meet The Professors: GIST Edition, Issue 1, 2008
This link privides a downloadable pdf and audio discussions of numerous case histories of GIST patients and their treatment decisions. The discussions include the following panel of experts: Charles D Blanke, MD, George D Demetri, MD, Burton L Eisenberg, MD, Brian Rubin, MD, PhD, and Jonathan C Trent, MD, PhD.
Evolving Molecular Medicine in GIST Management: A 2009 Update
Webcasts from CME held in January 2009.
Presenters include several well-known GIST experts: George Demetri, MD; Jonathan Fletcher, MD; John Vetto, MD; and Robert Benjamin, MD
Long-term survival in a Phase III Trial of Sunitinib in imatinib-resistant/-intolerant GIST with Novel Statistical Analysis to Account for Crossover
Poster presented at November 2008 CTOS meeting by CR Garrett, X Huang, PG Casali, P Schoffski, ME Blackstein, M Shah, J Verweij, V Tassel, CM Baum, and GD Demetri.
Click title to view pdf of poster, and use magnification control in Adobe Reader to enlarge and view one column at a time.
Detailed Analysis of Survival and Safety with Sunitinib in a Worldwide Treatment-use Trial of Patients with Advanced Imatinib-resistant/intolerant Gastrointestinal Stromal Tumor
by B. Seddon, P. Reichardt, YK Kang, W. Ruka, A Nieto, A Breazna, T. Lechner, and GD Demetri. Poster presented at November 2008 meeting of the Connective Tissue Oncology Society.
Click title to view pdf of poster, and use magnification control in Adobe Reader to enlarge and view one column at a time.
Development of a New Drug: Lessons from clinical trials
Paul Myers, MD Slide show from November 2008 CTOS meeting
Pfetin as a Prognostic Biomarker of Gastrointestinal Stromal Tumors Revealed by Proteomics
Presenter: Yoshiyuki Suehara
Slide show from November 2008 CTOS meeting.
Gastrointestinal Stromal Tumor (GIST) in Neurofibromatosis 1 (NF1) Patients: a Clinicopathologic Study of Nine Cases
Presenter: Paolo G. Casali
Slide show from November 2008 CTOS meeting.
Targeted Therapies and Effective Management of Patients With Gastrointestinal Stromal Tumors (GIST) or Chronic Myelogenous Leukemia
Andreas Hochhaus, MD; Jorge Cortes, MD; Margaret von Mehren, MD
An online medical education presentation hosted on Medscape. Medscape is free, but you have to register.
Molecular Therapy for GIST
Presenter: Peter Reichardt, MD PhD
Slide show presented July 2008 at a conference cosponsored by several German medical societies.
ASCO 2008 3-part Educational Session on GIST by Doctors Demetri, DeMatteo, and Blay
#1. Gastrointestinal Stromal Tumor (GIST) Comes of Age: Current Management Using Molecular Pathology, Surgery, and Targeted Therapies; Presenter: George D. Demetri, MD
#2. Surgical management of GIST including imatinib-refractory disease; Presenter: Ronald P. DeMatteo, MD, FACS
#3. Controversy in the adjuvant treatment of GIST; Presenter: Jean-Yves Blay, MD, PhD
Trough imatinib plasma levels in patients treated for advanced gastrointestinal stromal tumors evidence of large interpatient variations under treatment with standard doses.
Presenter: Binh N Bui, MD; Meeting: 2008 ASCO Annual Meeting; Session: Sarcoma (General Poster Session); Slide show only.
Prospective evaluation of prognostic factors for recurrence after complete surgical resection of gastrointestinal stromal tumors (GIST).
Presenter: Vijay S Suhag, MD Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (General Poster Session) Slideshow and audio
Does interruption of imatinib (IM) in responding GIST patients after one year of treatment influence the secondary resistance to IM after its reintroduction? Updated results of the prospective French Sarcoma Group randomized phase III trial on long term s
Presenter: David Perol, MD Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (General Poster Session) Slideshow only
Surgery in patients with metastatic or recurrent gastrointestinal stromal tumor (GIST) upon best response or limited progression following imatinib therapy.
Presenter: Ulrich Ronellenfitsch, MD Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (General Poster Session) Slideshow only
Continuous daily dosing (CDD) of sunitinib (SU) in pts with advanced GIST: Updated efficacy, safety, PK and pharmacodynamic analysis.
Presenter: Suzanne George, MD Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (General Poster Session) Slideshow only
A phase I study of nilotinib alone and in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors (GIST): Study update.
Presenter: Jean-Yves Blay, MD, PhD Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (General Poster Session) Slideshow only
Influence of complete resection of residual disease in responding patients to imatinib (IM) on the outcome of pts with advanced GIST: The experience of the BFR14 trial of the French Sarcoma Group.
Presenter: Eberhard Stoeckle, MD Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (General Poster Session) Slideshow only
Detailed analysis of survival and safety with sunitinib (SU) in a worldwide treatment-use trial of patients with advanced GIST.
Presenter: Peter Reichardt, MD Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (General Poster Session) Slideshow only
Novel statistical analysis of long-term survival to account for crossover in a phase III trial of sunitinib (SU) vs. placebo (PL) in advanced GIST after imatinib (IM) failure.
Presenter: George D. Demetri, MD Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (Poster Discussion) Slideshow only
Insulin-like growth factor 1 receptor (IGF-1R): A potential therapeutic target for gastrointestinal stromal tumors (GIST).
Presenter: Andrew K Godwin, PhD Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (Oral Presentation) Webcast and Slideshow
Time dependence of critical deletions as prognostic factor for relapse-free survival (RFS) in localised GIST. A Spanish Group for Sarcoma Research (GEIS) study.
Presenter: Javier Martin, MD Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (Oral Presentation) Slideshow and webcast
A phase I-II study of everolimus (RAD001) in combination with imatinib in patients (pts) with imatinib-resistant gastrointestinal stromal tumors (GIST).
Presenter: Herlinde Dumez Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (Poster Discussion) Slideshow only
Detection of cis-mutations in the activation loop of the KIT gene in sunitinib-resistant gastrointestinal stromal tumors.
Presenter: Toshirou Nishida, MD, PhD, FACS Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (Poster Discussion) Slideshow only
Does interruption of imatinib (IM) in responding patients after three years of treatment influence outcome of patients with advanced GIST included in the BFR14 trial?
Presenter: Antoine Adenis, MD, PhD Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (Poster Discussion) Slideshow only
Nilotinib in advanced GIST: A retrospective analysis of nilotinib in compassionate use.
Presenter: Michael Montemurro, MD Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (Poster Discussion) Slideshow only
Safety and tolerability of sunitinib (SU) initiated 24 h after the last dose of imatinib (IM) in advanced GIST.
Presenter: Paolo Giovanni Casali, MD Meeting: 2008 ASCO Annual Meeting Session: Sarcoma (General Poster Session) Slideshow
Inhibition of heat shock protein 90 (Hsp90) with the novel agent IPI-504 in metastatic GIST following failure of tyrosine kinase inhibitors (TKIs) or other sarcomas: Clinical results from phase I trial.
Presenter: Andrew J Wagner, MD, PhD Meeting: 2008 ASCO Annual Meeting Session: Emerging Targets for Sarcoma Therapy (Clinical Science Symposium) Webcast and Slideshow
Activity of sorafenib (SOR) in patients (pts) with imatinib (IM) and sunitinib (SU)-resistant (RES) gastrointestinal stromal tumors (GIST): A phase II trial of the University of Chicago Phase II Consortium.
Presenter: Lauren Wiebe, MD Meeting: 2008 ASCO Annual Meeting Session: Emerging Targets for Sarcoma Therapy (Clinical Science Symposium) Webcast and Slideshow
Multidisciplinary Management of Primary and Metastatic GIST
Presented by: Chandrajit P. Raut, MD, MSc. This webcast is the introductory welome to the session on GIST at the Society of Surgical Oncology 2008 meeting.
Multimodality Management of Primary Disease
Presented by: Ronald P. DeMatteo, MD. Webcast from the Society of Surgical Oncology 2008 meeting. You must accept a cookie to view this.
Medical Management of Metastatic Malignancy
Presented by: Charles D. Blanke, MD. Webcast from the Society of Surgical Oncology 2008 meeting. You must accept a cookie to view this.
Advances in Pathologic and Genetic Analysis
Presented by: Christopher L. Corless, MD, PhD. Webcast from the Society of Surgical Oncology 2008 meeting. You must accept a cookie to view this.
Surgical Management of Metastatic GIST
Presented by: Chandrajit P. Raut, MD, MSc. Webcast from the Society of Surgical Oncology 2008 meeting. You must accepet a cookie to view this.
Multidisciplinary Management of Primary and Metastatic GIST discussion
Discussion among the speakers in the Society of Surgical Oncology session on GIST, 2008. Webcast. You must accept a cookie to view this.
State-of-the-art tumor response assessment (at least in GIST).
Presenter: Robert S. Benjamin, MD. Slides from May 2008 ESMO Symposium on Sarcoma and GIST, Milan, Italy.
Note this is a Powerpoint presentation you can download. If you do not have the Microsoft Powerpoint software you can download a free Powerpoint viewer from Microsoft at THIS LINK.
Resistance to TKI: KIT and PDGFRA
Presenter: Maria Debiec-Rychter, PhD. Slides from May 2008 ESMO Symposium on Sarcoma and GIST, Milan, Italy.
Note this is a Powerpoint presentation you can download. If you do not have the Microsoft Powerpoint software you can download a free Powerpoint viewer from Microsoft at THIS LINK.
Natural history and standard treatment of GIST
Presenter: Peter Reichardt MD. Slide show from May 2008 ESMO Symposium on Sarcoma and GIST, Milan, Italy. Note this is a Powerpoint presentation you can download. If you do not have the Microsoft Powerpoint software you can download a free Powerpoint viewer from Microsoft at THIS LINK.
Pathology of GIST
Presenter: P.C.W. Hogendoorn MD Slides from May 2008 ESMO Symposium on Sarcoma and GIST, Milan, Italy.
Note this is a Powerpoint presentation you can download. If you do not have the Microsoft Powerpoint software you can download a free Powerpoint viewer from Microsoft at THIS LINK.
Molecular Biology of GIST
Presenter: Elena Tamborini MD Slides from May 2008 ESMO Symposium on Sarcoma and GIST, Milan, Italy.
Note this is a Powerpoint presentation you can download. If you do not have the Microsoft Powerpoint software you can download a free Powerpoint viewer from Microsoft at THIS LINK.
High Throughout Put Oncogene Mutation Profiling
Presenter: Massimo Loda MD Slides from May 2008 ESMO Symposium on Sarcoma and GIST, Milan, Italy.
Note this is a Powerpoint presentation you can download. If you do not have the Microsoft Powerpoint software you can download a free Powerpoint viewer from Microsoft at THIS LINK.
Delivering treatment: dose intensitiy and dose density?

Presenter: Axel Le Cesne MD Slides from May 2008 ESMO Symposium on Sarcoma and GIST, Milan, Italy.
Note this is a Powerpoint presentation that you can download. If you do not have the Microsoft Powerpoint software you can download a free Powerpoint viewer from Microsoft at THIS LINK.

Delivering treatment: pharmacology-driven therapy?

Presenter: Stefan Sleijfer MD Slides from May 2008 ESMO Symposium on Sarcoma and GIST, Milan, Italy.
Note this is a Powerpoint presentation you can download. If you do not have the Microsoft Powerpoint software you can download a free Powerpoint viewer from Microsoft at THIS LINK.

New avenues in GIST Treatment

Presenter: George Demetri MD Slides from May 2008 ESMO Symposium on Sarcoma and GIST, Milan, Italy.
Note this is a Powerpoint presentation that you can download. If you do not have the Microsoft Powerpoint software you can download a free Powerpoint viewer from Microsoft at THIS LINK.

An Interactive, Case-Based Approach to Targeted Therapies for GIST
Presenters: Charles D. Blanke, MD and Margaret von Mehren, MD webcast, May 2008, from Clinician's Channel
Correlation of imatinib plasma levels with clinical benefit in patients (Pts) with unresectable/metastatic gastrointestinal stromal tumors (GIST)
Presenter: George Demetri, MD webcast or slides from January 2008 ASCO Gastrointestinal Cancers Symposium
Efficacy of adjuvant imatinib mesylate following complete resection of localized, primary gastrointestinal stromal tumor (GIST) at high risk of recurrence: The U.S. Intergroup phase II trial ACOSOG9000
Presenter: Ronald DeMatteo, MD webcast or slides from January 2008 ASCO Gastrointestinal Cancers Symposium
Activity of sorafenib (SOR) in patients (pts) with imatinib (IM) and sunitinib (SU)-resistant (RES) GIST
A phase II trial of the University of Chicago Phase II Consortium Presenter: Halla S. Nimieri, MD webcast or slides from January 2008 ASCO Gastrointestinal Cancers Symposium
Gastrointestinal Stromal Tumor: Exploiting Molecular Mechanisms to Improve Patient Care
Speaker: Robert G. Maki, MD, PhD webcast or slides from January 2008 ASCO Gastrointestinal Cancers Symposium
New Challenges in Treating GIST: Which Target, What Agent, How Much, and When to Treat?
This is a webcast of a Novartis-sponsored ME seminar held in January 2008. The presenters and panelists are: George Demetri, MD; Burton Eisenberg, MD;, and Ronald DeMatteo, MD. You must register (for free) to watch the webcasts. You can also download Dr. Demetri's slides.
RECIST and Choi criteria for response assessment (RA) in patients with inoperable and metastatic gastrointestinal stromal tumours (GISTs) on imatinib mesylate. Cambridge GIST study group experience.
Presenter: Venkata R Bulusu, MD, MSc. 2007 ASCO Annual Meeting abstract 10019. Click icon under "Associated Presentation" below abstract.
Pathological significance of deletions involving codons 557 and 558 of KIT gene in localized resected gastrointestinal stromal tumors (GIST) of intermediate and high risk: a study by the Spanish Group for Sarcoma Research (GEIS).
Presenter: Ignacio Romero, MD. 2007 ASCO Annual Meeting abstract 10051. Click icon under "Associated Presentation" below abstract.
Inhibition of the Heat Shock Protein 90 (Hsp90) chaperone with the novel agent IPI-504 to overcome resistance to tyrosine kinase inhibitors (TKIs) in metastatic GIST: Updated results of a phase I trial.
Presenter: George D Demetri, MD. 2007 ASCO Annual Meeting abstract 10024. Click icon under "Associated Presentation" below abstract.
Subpopulation analyses in a worldwide treatment-use trial of sunitinib (SU) in GIST patients (pts) with resistance or intolerance to prior imatinib (IM) therapy.
Presenter: Peter Reichardt, MD. 2007 ASCO Annual Meeting abstract 10022. Click icon under "Associated Presentation" below abstract.
Continuous daily dosing (CDD) of sunitinib malate (SU) compares favorably with intermittent dosing in pts with advanced GIST.
Presenter: Suzanne George, MD. 2007 ASCO Annual Meeting abstract 10015. Click icon under "Associated Presentation" below abstract.
Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors (GIST): A meta-analyis based on 1,640 patients (pts).
Presenter: Martine M Van Glabbeke, PhD 2007 ASCO Annual Meeting abstract 10004
Adjuvant imatinib mesylate increases recurrence free survival (RFS) in patients with completely resected localized primary gastrointestinal stromal tumor (GIST): North American Intergroup Phase III trial ACOSOG Z9001
Speaker: Ronald DeMatteo, MD 2007 ASCO Annual Meeting abstract 10079 Click icon under "Associated Presentation" below the abstract.
A phase I study of nilotinib alone and in combination with imatinib (IM) in patients (pts) with imatinib-resistant gastrointestinal stromal tumors (GIST) - Study update.
Presenter: Margaret Von Mehren, MD 2007 ASCO Annual Meeting
Rare incidence of congestive heart failure (CHF) in gastrointestinal stromal tumor (GIST) and other sarcoma patients (pts) receiving imatinib mesylate (IM) therapy.
Presenter: Aarif Y Khakoo, MD 2007 ASCO Annual Meeting abstract 10026
Interruption of imatinib (IM) in GIST patients with advanced disease after one year of treatment: Updated results of the prospective French Sarcoma Group randomized phase III trial on long term survival.
Presenter: Maria RIOS, MD 2007 ASCO Annual Meeting abstract 10016
Evaluation of soluble KIT (sKIT) as a potential surrogate marker for TTP in sunitinib malate (SU)-treated patients (pts) with advanced GIST.
Presenter: Martin Blackstein, MD, PhD 2007 ASCO Annual Meeting abstract 10007
Relationship between compliance with imatinib mesylate and medical costs for patients with CML and GIST.
Presenter: Rachel Halpern, PhD, MPH 2007 ASCO Annual Meeting abstract 6618
Perioperative morbidity in metastatic gastrointestinal stromal tumors (GIST) undergoing surgery of residual disease following imatinib (IM).
Presenter: Alessandro Gronchi, MD 2007 ASCO Annual Meeting abstract 10043
Mechanisms of sunitinib malate (SU) resistance in gastrointestinal stromal tumors (GISTs).
Presenter: Michael C Heinrich, MD 2007 ASCO Annual Meeting abstract 10006
Continuous versus interruption of imatinib (IM) in responding patients with advanced GIST after three years of treatment: A prospective randomized phase III trial of the French Sarcoma Group
Presenter: Axel Le Cesne, MD 2007 ASCO Annual Meeting abstract 10016
Evaluation of imatinib mesylate (IM) in patients with large volume gastrointestinal stromal tumors (GISTs).
Presenter: Dan M Byrd, MD 2007 ASCO Annual Meeting, abstract 10054
Perioperative sunitinib dosing around extensive resections of imatinib-resistant metastatic gastrointestinal stromal tumors.
Presenter: Chandrajit P Raut, MD, MSc 2007 ASCO Annual Meeting abstract 10044
Treatment Update on GIST
Presenters: Michael Heinrich, MD and George Demetri, MD Teleconference recording from January 2007, sponsored by CancerCare.
Molecular Targeted Therapies and Diagnostics in GIST: Lessons Learned in Clinical Development.
Presenter: George Demetri, MD (October 2006). This webcast from The DAVE Project is a lecture by Dr. Demetri to gastroenterology residents.
The DAVE Project film of gastric GIST.
This narrated film clip shows the endoscopic view of a gastric GIST. It was produced by Doctors PS Sepe & PB Kelsey of Massachusetts General Hospital.
GIST: The Use of Detailed Mutational Analysis to Guide Therapy
Presentation by Charles Blanke, MD. January 2007 ASCO Gastrointestinal Cancers Symposium. Webcast or slides (your choice). Click the "video" or "slides" icon to the right of the name Charles Blanke on the linked page.
Inhibition of heat shock protein 90 (Hsp90) with the novel agent IPI-504 to overcome resistance to tyrosine kinase inhibitors (TKIs) in metastatic GIST: Results of a phase I trial.
Presenter: George D. Demetri, MD. January 2007 ASCO Gastrointestinal Cancer Symposium. View as slides OR listen as webcast. Click desired icon "slides" or "video" at #2 below abstract.
CancerCare teleconference audio archive
The organization CancerCare, sponsored by Pfizer Oncology, presented an important educational opportunity for GIST patients and their families. CancerCare held a FREE telephone educational workshop on January 30, 2007. Oncologists Michael Heinrich, MD and George Demetri, MD were the speakers. "Treatment Update on GIST" Access a replay of the one-hour teleconference at this link:
Third GIST Global Opinion Leader Summit
Educational materials from the Third GIST Global Opinion Leader Summit meeting, "Multi-modality Approaches to Treating Patients with GIST" are available at a website set up for their distribution. This meeting, held in Prague on October 27-29, 2006, was supported by an unrestricted grant from Novartis Oncology. The co-chairs for the meeting were Jean-Yves Blay, MD PhD and Peter Reichardt, MD PhD, both well-known GIST experts. There are numerous presentations covering many GIST topics available at this website link, and the user can choose either to view the presentations as webcasts (listening to the speakers) or to view only the slides (no audio).
Multitargeted Agents Show Promise for Improving Outcomes in the Treatment of Solid Tumors
by Robert A. Figlin, MD Presented 2006 or University of Florida & "PeerView in Review"
Expanding Role of Multitargeted Agents in the Treatment of Gastrointestinal Stromal Tumors
by Michael C. Heinrich, MD Presented 2006 at University of Florida.
Current Therapies Improve Outcomes for Patients with Gastrointestinal Stromal Tumors
by Charles D. Blanke, MD presented 2006 or University of Florida & Peer View in Review
New Treatments Active in Imatinib-Resistant Gastrointestinal Stromal Tumors
by Margaret von Mehren, MD presented 2006 sponsored by University of Florida & PeerView in Review
Current Clinical management of GIST: Maintaining Disease Control
by Robert Maki, MD presented December 2005 for University of Florida & Peer View in Review
Sunitinib (SU) response in imatinib-resistant (IM-R) GIST correlates with KIT and PDGFRA mutation status.
Presenter: Michael C. Heinrich. MD ASCO 2006 abstract 9502, viewable either as webcast or as slide show. Click desired presentatoin icon beneath abstract to view.
Do patients with initially resected metastatic GIST benefit from 'adjuvant' imatinib (IM) treatment? Results of the prospective BFR14 French Sarcoma Group randomized phase III trial.
Presenter: Binh N. Bui, MD ASCO 2006 abstract 9501, viewable either as webcast or as slide show. Click desired presentation icon beneath abstract to view.
Indication and results of surgery following imatinib treatment of locally advanced or metastatic GI stromal tumors (GIST).
Presenter: Peter Hohenberger, MD ASCO 2006 abstract 9500, viewable either as webcast or as slide show. Click desired presentation icon beneath abstract to view.
Response of gastrointestinal stromal tumors (GISTs) to imatinib by Choi criteria and response evaluation criteria in solid tumors (RECIST) as surrogates for survival and time to progression.
Presenter: Robert S. Benjamin, MD ASCO 2006 abstract 9506, viewable either as webcast or as slide show. Click desired presentation icon beneath abstract to view.
Discussion segments, session "Gastrointestinal Stromal Tumors: Multimodal Approach"
From the linked page you can select from discussion segments led by the following discussants: Discussion leaders: 1) George Demetri, MD 2) Chandrajit Raut, MD 3) Margaret von Mehren, MD 4) Ian Judson, MD ASCO 2006, discussion webcasts available, as well as slides shown by discussants. Click the desired icon to the right of the discussant's name.
Sunitinib treatment of pediatric metastatic GIST after failure of imatinib.
Presenter: Katherine Janeway, MD ASOC 2006 abstract 9519, slide show. Click "slides" icon beneath abstract to view slides.
Phase II study of sunitinib administered in a continuous daily dosing regimen in patients (pts) with advanced GIST
Presenter: Suzanne George, MD ASCO 2006 abstract 9532, slide show. Click "slides" icon beneath abstract to view.
Loss of heterozygosity with acquisition of homozygous KIT-activating mutation promotes gastrointestinal stromal tumor progression.
Presenter: Lei L. Chen, MD PhD ASCO 2006 abstract 9530, slide show. Click "slides" icon beneath abstract to view.
Familial gastrointestinal stromal tumor with homo-/hemizygous kit exon 11 deletion: Genotypic, histopathologic, radiographic, and therapeutic findings.
Presenter: Eric P. Kleinbaum ASCO 2006 abstract 9527, poster. Click "slides" icon beneath abstract. (Note that this will show a single image of the entire poster, so it is very small and hard to read.)
Evaluation of SRC-family kinases in gastrointestinal stromal tumors.
Presenter: Sebastian Bauer, MD ASCO 2006 abstract 9529, slide show. Click "slides" icon beneath abstract.
A phase II, open-label study of PTK787/ZK222584 in the treatment of metastatic gastrointestinal stromal tumors (GISTs) resistant to imatinib mesylate.
Presenter: Heikki Joensuu. MD ASCO 2006 abstract 9531, slide show. Click "slides" icon beneath abstract.
Surgical interventions for focal progression of gastrointestinal stromal tumors under imatinib therapy.
Presenter: Toshirou Nishida, MD PhD ASCO 2006 abstract 9548, slide show. Click "slides" icon beneath abstract.
reGISTry: An observational registry of gastrointestinal stromal tumor (GIST) patients (pts) in the USA.
Presenter: Jonathan C Trent, MD ASCO 2006 slide show of abstract 9543. Click "slides" icon beneath abstract.
Pediatric GIST: the new kid on the block.
Presenter: Alberto S. Pappo, MD ASCO 2006 presentation viewable as webcast only (not as slide show). Click video icon on linked page.
Updated results from a phase III trial of sunitinib in GIST patients (pts) for whom imatinib (IM) therapy has failed due to resistance or intolerance.
Presenter: Paolo Casali. MD ASCO 2006 presentation viewable as webcast or slide show.
Increase of creatine kinase value (CK) correlates with muscoloskeletal complaints (MSC) in GIST patients during imatinib therapy.
Presenter: Paolo Allione, MD ASCO 2006. Viewable as webcast or as slide show.
Anti-VEGF Therapy for Solid Malignancies: Clinical Results and Surgical Issues
Presenter: Lee M. Ellis, MD Slide show from Society of Surgical Oncology meeting, March 2006
Improved survival and sustained clinical benefit with SU11248 (SU) in pts with GIST after failure of imatinib mesylate therapy in a phase III trial
Presenter: George Demetri, MD Webcast from ASCO Gastrointestinal Cancers Symposium, January 2006. After clicking link, then click the "VIDEO" icon to the right of Dr. Demetri's name.
Outcome of advanced GIST patients treated with imatinib mesylate: four-year follow-up of a randomized Phase II trial
Presenter: Charles Blanke, M.D. ASCO Gastrointestinal Cancer Symposium, January 2006 Webcast (slides plus audio) available. After clicking the link, then click the "VIDEO" icon to the right of Dr. Blanke's name.
Surgical management of advanced GIST following KIT-directed therapy
Authors: CP Raut, M Posner, J Desai, GD Demetri, JA Morgan, S George, D Zahrieh, CDM Fletcher, MM Bertagnolli Slide show presented at CTOS, November 2005 (requires Powerpoint viewer)
Targeting HSP90 in imatinib-resistant GIST
Authors: S Bauer, L Yu, GD Demetri, JA Fletcher Slide show presented at CTOS, November 2005 (requires Powerpoint viewer)
Advanced Gastrointestinal stromal tumor: molecular, pathological and clinical pattern in post-imatinib surgery
Authors: A Gronchi, M Fiore, R Bertulli, E Tamborini, P Collini, S Pilotti, C Mussi, P Coco, A Messina, S Stacchiotti, PG Casali Slide show from CTOS, November 2005 (requires Powerpoint viewer, slow download)
The Era of Molecularly Targeted Therapy: redefining the treatment of GIST
Presenter: Gianluca Fincato, MD Western Europe Medical Affairs Director, Novartis Date: June 2005, Dublin Ireland Meeting: "New Horizons in Treating Cancer: Third International Conference for Organizations Representing People with CML or GIST"
Summary of ESMO Consensus on GIST and current research
Presenter: Peter Reichardt, MD Date: June 2005, Dublin Ireland Meeting: "New Horizons in Treating Cancer: Third International Conference for Organizations Representing People with CML or GIST"
Special Plenary Lecture: Correlation of target kinase genotype with clinical activity of imatinib mesylate (IM) in patients with metastatic GISTs
Presenter: Michael C. Heinrich, MD ASCO, May 2005 After clicking the link, click "Audio & Slides (below the abstract) to view presentation.
Imaging kinase target inhibition with SU11248 by FDG-PET in patients (pts) with imatinib-resistant gastrointestinal stromal tumors (I-R GIST)
Presenter: Annick D. Van den Abbeele, MD ASCO. May 2005 After clicking the link, click either "Video" (to hear the talk) or "Slides" (to see slides without audio).
Phase 3, multicenter, randomized, double-blind, placebo-controlled trial of SU11248 in patients (pts) following failure of imatinib for metastatic GIST
Presenter: George D. Demetri, MD ASCO, May 2005 After clicking link, click "video" to hear and view presentation.
Apoptotic and anti-vascular activity of imatinib in GIST patients
Presenter: Jonathan C. Trent, MD AACO May 2005 Ater clicking link, click "Video" to hear and view presentation.
Results from a continuation trial of SU11248 in patients with imatinib (IM)-resistant gastrointestinal stromal tumor (GIST)
Presenter: Robert G. Maki, MD, PhD ASCO, May 2005 After clicking the link, click either "Video" (to hear the talk) or "Slides" (to see slides without audio).
Clinical benefit of imatinib in patients (pts) with metastatic gastrointestinal stromal tumors (GIST) negative for the expression of CD117 in the S003
Presenter: Martin E Blackstein, MD, PhD, FACP ASCO, May 2005 After clicking the link, click either "Video" (to hear the talk) or "Slides" (to see slides without audio).
Adjuvant imatinib mesylate in patients with primary high risk gastrointestinal stromal tumor (GIST) following complete resection: Safety results
Presenter: Ronald P. DeMatteo, MD ASCO, May 2005 After clicking the link, click either "Video" (to hear the talk) or "Slides" (to see slides without audio).
FDG PET but not RECIST agrees with histologic response of soft tissue sarcoma to neoadjuvant chemotherapy
Presenter: Scott M. Schuetze, MD, PhD ASCO, May 2005 After clicking the link, click "Video" to hear and view presentation.
Safety and pharmacokinetics of AMG 706 in patients with advanced solid tumors
Presenter: Lee Rosen, MD ASCO, May 2005 After clicking the link, click "Video" to hear and view presentation.
Pharmacodynamic analysis of target receptor tyrosine kinase activity and apoptosis in GIST tumors responding to therapy with SU11248
ASCO, May 2005 Presenter: Darren W. Davis, Ph.D. After clicking the link, click "Video" to hear and view presentation.
Rational Treatment Options for GIST: Gleevec, SU11248, RAD001 and Beyond
Webcast of presentation made in November 2004 by George D. Demetri, M.D. at the Chemotherapy Foundation Symposium and Online Education Program, Mount Sinai School of Medicine. After linking to the MSSM site, scroll down to the GI Cancers section and click beside the presentation title for Dr. Demetri's talk.
Systemic Management of Primary GIST
Webcast presented by Peter Reichardt, M.D. in April 2004 to the Chinese Society of Clinical Oncology. After linking to CSCO site, scroll down to the 11:10 am time slot on Saturday and click the link for Dr. Reichardt's presentation.
GIST - Current and Future Clinical Trials
Milind Javle, MD Slide presentation at the November 2004 NCCN GIST conference, Roswell Park Cancer Institute.
18F-FDG PET -- a metabolic tool to grade treatment response in advanced gastrointestinal stromal tumor (GIST)
Dominick Lamonica, MD RPCI Slide show presented at the November 2004 NCCN conference on GIST, Roswell Park Cancer Institute.
Staging and surgical therapy for primary and recurrent gastrointestinal stromal tumors
John M. Kane III, MD Slide presentation at the Nov. 2004 NCCN GIST conference, Roswell Park Cancer Institute.
The pathology of gastrointestinal stromal tumors
Charles M. LeVea, MD PhD Slide show presented at the November 2004 NCCN conference on GIST, Roswell Park Cancer Institute.
Medical management of GIST
Michael Morse, MD This slide show was presented at the November 2004 NCCN GIST conference, Roswell Park Cancer Institute.
Interactive Tumor Board: Case no. 1: Gastric GIST
Benjamin F. Calvo, MD slide show presented at the October 2004 annual clinical congress, American College of Surgeons
Localized GIST in the Gleevec Era
Slide show by Ronald P. DeMatteo, M.D. at the October 2004 Annual Clinical Congress, American College of Surgeons
Prognostic factors for initial and late resistance to imatinib in patients with advanced GIST
Van Glabbeke M et al (group of authors from EORTC-ISG-AGIGT) Slides (in Powerpoint software) from presentation at the Connective Tissue Oncology Society meeting, Nov. 2004.
Acquired resistance to imatinib in GIST due to multiple kinase-domain mutations of KIT
Slides presented by Wardelmann et al PowerPoint slides from Connective Tissue Oncology Society, Nov. 2004 Note that this may take a long time to download.
A comparison of patterns of tumor response to molecular-targeted therapy in GIST and chordoma
Casali et al Powerpoint slides from presentation at CTOS, Nov, 2004
The management of gastrointestinal stromal tumors and Recognizing and managing resistance to imatinib mesylate in patients with metastatic GIST
This webcast by Charles D. Blanke, MD was presented on 6/19/2004 at the World Congress on Gastrointestinal Cancer. It consists of two papers webcast back-to-back. The second part was authored by George Demetri, MD, but Dr. Blanke gave the oral presentation in Dr. Demetri's absence. NOTE that this webcast will not play in some browsers but does work fine in Internet Explorer.
Molecular events in gastrointestinal stromal tumors
This webcast was presented by Maria Debiec-Rychter, MD PhD on 6/19/2004 at the World Congress on Gastrointestinal Cancer. NOTE that this webcast works fine in Internet Explorer but does not play in some other browsers.
Is a PET scan a necessary tool in the treatment of gastrointestinal stromal tumors?
This webcast by Sigrid Stroobrants, MD PhD was presented on 6/19/2004 at the World Congress on Gastrointestinal Stromal Tumors. NOTE that this webcast works in Internet Explorer but does not play in some other browsers.
Long-term followup of advanced gastrointestinal stromal tumor (GIST) patients treated with imatinib mesylate
Webcast presentation by Charles Blanke, MD ASCO 2004 Gastrointestinal Cancers Symposium Once you have linked to the ASCO site, click the icon for "Video" to start the webcast.
NCCN GIST Webcast
Dr. George Demetri and Dr. Ronald DeMatteo are this presenters in this comprehensive webcast summarizing a task force report from the National Comprehensive Cancer Network. This webcast has been removed from the NCCN site. A limited number of copies of a CD-ROM containing the webcast may be available through NCCN.
Imatinib may enable complete resection in previously unresectable or metastatic GIST.
Presenter: Sebastian Bauer, MD ASCO 2004 meeting abstract 9023 Link to AASCO site, then click "Slides" icon (look below abstract) to view slides.
SU11248 can overcome imatinib resistance caused by diverse genomic mechanisms in patients with metastatic GIST
Presenter: George D. Demetri, MD ASCO 2004 annual meeting abstract 3001 After linking to the ASCO page, click "Video" to start webcast (look below the abstract).
Combination signal transduction inhibition: a phase I/II trial of ... RAD001 and imatinib in patients with GIST refractory to imatinib
Presenter:AT van Oosterom, MD PhD 2004 ASCO meeting abstract 3002 After linking to the ASCO page, click "Video" icon to start webcast (look below the abstract).
Activity and tolerability of the multi-targeted tyrosine kinase inhibitor SUO11248 in patients with metastatic GIST refractory to imatinib mesylate
Presenter: Jayesh Desai, MD ASCO 2004 Gastrointestinal Cancers Symposium abstract 7 After linking to ASCO page, click "video" icon to play the webcast (look below the abstract).
Gastrointestinal Stromal Tumors
Presenter: AT van Oosterom, MD PhD ASCO 2004 annual meeting. Link to ASCO, then click icon for "Video" under the listing numbered as "2. Gastrointestinal Stromal Tumors."
Emerging Issues: biology and management of GIST
Presenter: S. Patel, MD ASCO 2004 annual meeting Link to the ASCO site, then scroll down the page to the last discussion entry by Dr. Patel, then click "Video" to the right of Dr. Patel's name to play the lecture.
p53 mutations in GIST: pattern and prognostic significance
Presenter: M-H Ryu, MD 2004 ASCO meeting abstract 9026 Link to the ASCO page, then click "Slides" icon below the abstract to view slides (no sound).
Use of CT as an early prognostic indicator of response to imatinib mesylate in patients with GIST
Presenter: CH Holdsworth, PhD 2004 ASCO meeting abstract 3011. Link to ASCO site, then click "slides" to view.
Safety and efficacy of percutaneous radio-frequency ablation in patients with metastatic GIST with clonal evolution of lesions refractory to imatinib
Presenter P. Dileo, MD 2004 ASCO meeting abstract 9024 Link to ASCO site, then click "slides" to view (look below abstract).
Prognostic value of pathologic variables and mutations type in patients with complete surgical resection of GIST, a GEIS study
Presenter: J. Martin, MD 2004 ACSO meeting abstract 9029 Link to ASCO site, then click "slides" icon (look below abstract) to view.
Effects of cessation of imatinib mesylate therapy in patients with imatinib-refractory GIST as visualized by FDG-PET scanning
Slide presentation by AD Van den Abbeele, MD ASCO 2004 meeting abstract 3012 Link to ASCO site, then click "slides" icon (look below abstract) to view.
Clonal evolution of resistance to imatinib in patients with GIST: molecular and radiologic evaluation of new lesions
Presenter: Jayesh Desai, MD ASCO 2004 meeting abstract 3010 Link to ASCO site, then click "slides" icon (look below abstract) to view.
Risk estimation with tumor size, serosal invasion and MIB-1 labeling index for GIST of the stomach
Slide presentation by H. Cho, MD at 2004 ASCO meeting. Link to ASCO site, then click "slides" to view.
ASCO 2003 Session on Sarcoma
This session includes several presentations on GIST. Link to the ASCO site, then scroll down the page to find and select the desired presentations from this list. Sarcoma Robert G Maki, MD, PhD (Discussant) Phase III dose-randomized study of imatinib mesylate (STI571) for GIST: Intergroup S0033 early results. Abstract No: 3271 Robert S Benjamin, MD Early efficacy comparison of two doses of imatinib for the treatment of advanced gastro-intestinal stromal tumors (GIST): Interim results of a randomized phase III trial from the EORTC-STBSG, ISG and AGITG. Abstract No: 3272 Jaap Verweij, MD, PhD Clinical activity and tolerability of the multi-targeted tyrosine kinase inhibitor SU11248 in patients (pts) with metastatic gastrointestinal stromal tumor (GIST) refractory to imatinib mesylate. Abstract No: 3273 George D. Demetri, MD PDGFRA and KIT mutations correlate with the clinical responses to imatinib mesylate in patients with advanced gastrointestinal stromal tumors (GIST) Abstract No: 3274 Michael C Heinrich, MD Mechanisms of resistance to imatinib mesylate (IM) in advanced gastrointestinal stromal tumor (GIST) Abstract No: 3275 Jonathan A. Fletcher, MD Below is the link to view the ASCO page containing the above presentation links:
Therapeutic options for gastrointestinal stromal tumors
Presenter: Charles D. Blanke, MD ASCO 2003 meeting. Link to the ASCO site, then click "Video" (look below abstract) to start webcast.
Gastrointestinal stromal tumors: diagnosis, epidemiology, prognosis
Presenter: L-G Kindblom, MD ASCO 2003 meeting. Link to the ASCO site, then click "Video" (look to right of Dr. Kindblom's name)to start the webcast.
Clinical activity and tolerability of the multi-targeted tyrosine kinase inhibitor SU11248 in patients (pts) with metastatic gastrointestinal stromal
Presenter: GD Demetri, MD ASCO 2003 meeting abstract 3273. Link to ASCO and click "slides" to view (look below abstract).
Mechanisms of resistance to imatinib mesylate (IM) in advanced gastrointestinal stromal tumor (GIST)
Presenter: JA Fletcher, MD ASCO 2003 meeting abstract 3275. Link to ASCO, then click "slides" to view (look below abstract).
STI-571 in GI Stromal Tumors
Presenter: George D. Demetri, MD 2001 Chemotherapy Foundation Symposium and Online Education Program, Mount Sinai School of Medicine. After linking to the MSSM site, scroll down to the "Novartis" section of the program and you will see the clicker to view the presentattion for Dr. Demetri.
Clinical Management of GIST: Understanding the New Paradigms
This is a CME publication covering key clinical issues in the management of GIST including highlights from the 2003 Connective Tissue Oncology Society annual meeting and the Helsinki Gist Symposium. It was released in April 2004. While not strictly a slide show, this booklet contains graphics from many different presentations by experts.
Evaluation of the safety and efficacy of an oral molecularly-targeted therapy, STI-571, in patients with unresectable or metastatic GISTs
Presenter: Charles Blanke, MD ASCO 2001 meeting plenary lecture. This was the first presentation about Gleevec trials for GIST. Link to ASCO site, click "Video" to start the webcast (look to the right of Dr. Blanke's name).


back to top