NF1 is a condition characterized by multiple cafe au lait spots, freckling, neurofibromas of the skin, and Lisch nodules in the iris of the eyes. Less common but potentially more serious manifestations include a variety of tumors. Heterozygous mutations of the NF1 gene are responsible for the vast majority of cases of neurofibromatosis. The NF1 gene encodes the tumor-suppressor protein neurofibromin. GISTs are unusually common in persons with NF1, occurring in 5-25% of affected people; the GISTs are usually located in the small intestine and are usually multiple, but they may not cause any symptoms. A comprehensive discussion of NF1 is provided at this link: linkhere

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