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Current Trials for GIST Cancer

Current clinical trials for GIST (gastrointestinal stromal tumor) are linkable entries in the list below, grouped by the type of drug being evaluated, plus drug combinations.

For more information about a drug, see its named page under our Emerging Treatments tab.

 

Maps of Trial Locations

When you click this link you will see a world map of GIST cancer trials at the clinicaltrials.gov website.  In countries where there are trials you will see a small white block with a black number indicating how many trials are open there.  Click the black number to zoom in on the geographic area of your choice.  For example, if you click on the USA or Europe, another map will open showing trials in each state or country.  Click again on the state or country of your choice to see which trials are available there.  NOTE that some trials listed in the table below will NOT appear on this map if GIST is not specifically listed in the trial protocol; for example, trials for any solid tumor may not appear. 

 

Current Trials by Drug Target

Clinical trials for GIST cancer are listed below according to the class of drug being tested (the target of the drug).  For each drug listed under each category, click "Trials at clinicaltrials.gov" to see the open trials relevant to GIST patients at the website www.clinicaltrials.gov.

NOTE:  Drugs that are already FDA-approved for other cancers may be prescribed at the discretion of a physician outside of a clinical trial.  These drugs are indicated in the list below by "brand name" following the chemical name.


Tyrosine Kinase Inhibitors of KIT and/or PDGFRA 

Nilotinib (brand name Tasigna):   Trial at Fox-Chase  Trials at clinicaltrials.gov

Sorafenib (brand name Nexavar):  Trials at clinicaltrials.gov

Pazopanib (brand name Votrient): Trials at clinicaltrials.gov

Dasatinib (brand name Sprycel):  Trials at clinicaltrials.gov

Masitinib (AB1010): Trials at clinicaltrials.gov

Regorafenib:  Trials at clinicaltrials.gov

Crenolanib  (CP-868,596): Trials at clinicaltrials.gov

OSI-930Trials at clinicaltrials.gov

Cediranib (AZD2171)Trials at clinicaltrials.gov

Amuvatinib (MP470): Trials at clinicaltrials.gov 

Dovitinib (TKI258) : Trials at clinicaltrials.gov

DCC-2618: (trial expected to open) Trials at clinicaltrials.gov

 

Biologic Inhibitors of KIT or PDGFRA

Olaratumab (IMC-3G3):  Trials at clinicaltrials.gov

 

HSP90 Inhibitors

Ganetespib STA-9090: Trials at clinicaltrials.gov

Retaspimycin (IPI-504): Trials at clinicaltrials.gov

Tanespimycin (17-AAG, KOS-953): Trials at clinicaltrials.gov

SNX-5422: Trials at clinicaltrials.gov

AUY922: Trials at clinicaltrials.gov

AT13387: Trials at clinicaltrials.gov

 

Inhibitors of Pathways Downstream of KIT & PDGFR

RAS/RAF/MEK/ERK/MAPK inhibitors:


XL281Trials at clinicaltrials.gov

RDEA119Trials at clinicaltrials.gov 

GDC-0973 (XL518):  Trials at clinicaltrials.gov

Selumetinib (AZD6244): Trials at clinicaltrials.gov

BAY86-9766Trials at clinicaltrials.gov

 

AKT inhibitors: 

perifosineTrials at clinicaltrials.gov

XL418Trials at clinicaltrials.gov


mTOR inhibitors


everolimus (RAD001):  Trials at clinicaltrials.gov

sirolimus (brand name Rapamune):  Trials at clinicaltrials.gov

temsirolimus (brand name Torisel):  Trials at clinicaltrials.gov

deforolimus AP23573:  Trials at clinicaltrials.gov

PF-04691502Trials at clinicaltrials.gov

 

PI3K inhibitors


BEZ235Trials at clinicaltrials.gov

SF1126Trials at clinicaltrials.gov

XL147Trials at clinicaltrials.gov

XL765 (also inhibits mTOR):  Trials at clinicaltrials.gov

PX-866Trials at clinicaltrials.gov

GDC-0941 bismesylateTrials at clinicaltrials.gov

GDC-0980 (also inhibits mTOR):  Trials at clinicaltrials.gov

PF-04691502Trials at clinicaltrials.gov

BAY80-6946:

BYL719:  Trials at clinicaltrials.gov

Buparlisib (BKM120):  Trials at clinicaltrials.gov

 

Cell Cycle Inhibitors

Vorinostat (brand name Zolinza):  Trials at clinicaltrials.gov

Ixabepilone (brand name Ixempra):  Trials at clinicaltrials.gov

CUDC101Trials at clinicaltrials.gov

PanobinostatTrials at clinicaltrials.gov

 
Insulin-like Growth Factor Pathway Inhibitors


BIIB022Trials at clinicaltrials.gov

AMG 479Trials at clinicaltrials.gov

MK0646Trials at clinicaltrials.gov

Figitumumab (CP-751,871):  Trials at clinicaltrials.gov

Linsitinib (OSI-906):  Trials at clinicaltrials.gov

XL228Trials at clinicaltrials.gov

Cixutumumab (IMC-A12):  Trials at clinicaltrials.gov

MEDI-573Trials at clinicaltrials.gov


 


This page is always under revision, and more trials will be added as they are identified. 


 



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