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Current Trials for GIST Cancer
Current clinical trials for GIST (gastrointestinal stromal tumor) are linkable entries in the list below, grouped by the type of drug being evaluated, plus drug combinations.
For more information about a drug, see its named page under our Emerging Treatments tab.
Maps of Trial Locations
When you click this link you will see a world map of GIST cancer trials at the clinicaltrials.gov website. In countries where there are trials you will see a small white block with a black number indicating how many trials are open there. Click the black number to zoom in on the geographic area of your choice. For example, if you click on the USA or Europe, another map will open showing trials in each state or country. Click again on the state or country of your choice to see which trials are available there. NOTE that some trials listed in the table below will NOT appear on this map if GIST is not specifically listed in the trial protocol; for example, trials for any solid tumor may not appear.
Current Trials by Drug Target
Clinical trials for GIST cancer are listed below according to the class of drug being tested (the target of the drug). For each drug listed under each category, click "Trials at clinicaltrials.gov" to see the open trials relevant to GIST patients at the website www.clinicaltrials.gov.
NOTE: Drugs that are already FDA-approved for other cancers may be prescribed at the discretion of a physician outside of a clinical trial. These drugs are indicated in the list below by "brand name" following the chemical name.
Tyrosine Kinase Inhibitors of KIT and/or PDGFRA
Nilotinib (brand name Tasigna): Trial at Fox-Chase Trials at clinicaltrials.gov
Sorafenib (brand name Nexavar): Trials at clinicaltrials.gov
Pazopanib (brand name Votrient): Trials at clinicaltrials.gov
Dasatinib (brand name Sprycel): Trials at clinicaltrials.gov
Masitinib (AB1010): Trials at clinicaltrials.gov
Regorafenib: Trials at clinicaltrials.gov
Crenolanib (CP-868,596): Trials at clinicaltrials.gov
OSI-930: Trials at clinicaltrials.gov
Cediranib (AZD2171): Trials at clinicaltrials.gov
Amuvatinib (MP470): Trials at clinicaltrials.gov
Dovitinib (TKI258) : Trials at clinicaltrials.gov
DCC-2618: (trial expected to open) Trials at clinicaltrials.gov
Biologic Inhibitors of KIT or PDGFRA
Olaratumab (IMC-3G3): Trials at clinicaltrials.gov
HSP90 Inhibitors
Ganetespib STA-9090: Trials at clinicaltrials.gov
Retaspimycin (IPI-504): Trials at clinicaltrials.gov
Tanespimycin (17-AAG, KOS-953): Trials at clinicaltrials.gov
SNX-5422: Trials at clinicaltrials.gov
AUY922: Trials at clinicaltrials.gov
AT13387: Trials at clinicaltrials.gov
Inhibitors of Pathways Downstream of KIT & PDGFR
RAS/RAF/MEK/ERK/MAPK inhibitors:
XL281: Trials at clinicaltrials.gov
RDEA119: Trials at clinicaltrials.gov
GDC-0973 (XL518): Trials at clinicaltrials.gov
Selumetinib (AZD6244): Trials at clinicaltrials.gov
BAY86-9766: Trials at clinicaltrials.gov
AKT inhibitors:
perifosine: Trials at clinicaltrials.gov
XL418: Trials at clinicaltrials.gov
mTOR inhibitors
everolimus (RAD001): Trials at clinicaltrials.gov
sirolimus (brand name Rapamune): Trials at clinicaltrials.gov
temsirolimus (brand name Torisel): Trials at clinicaltrials.gov
deforolimus AP23573: Trials at clinicaltrials.gov
PF-04691502: Trials at clinicaltrials.gov
PI3K inhibitors
BEZ235: Trials at clinicaltrials.gov
SF1126: Trials at clinicaltrials.gov
XL147: Trials at clinicaltrials.gov
XL765 (also inhibits mTOR): Trials at clinicaltrials.gov
PX-866: Trials at clinicaltrials.gov
GDC-0941 bismesylate: Trials at clinicaltrials.gov
GDC-0980 (also inhibits mTOR): Trials at clinicaltrials.gov
PF-04691502: Trials at clinicaltrials.gov
BAY80-6946:
BYL719: Trials at clinicaltrials.gov
BKM120: Trials at clinicaltrials.gov
Cell Cycle Inhibitors
Vorinostat (brand name Zolinza): Trials at clinicaltrials.gov
Ixabepilone (brand name Ixempra): Trials at clinicaltrials.gov
CUDC101: Trials at clinicaltrials.gov
Panobinostat: Trials at clinicaltrials.gov
Insulin-like Growth Factor Pathway Inhibitors
BIIB022: Trials at clinicaltrials.gov
AMG 479: Trials at clinicaltrials.gov
MK0646: Trials at clinicaltrials.gov
Figitumumab (CP-751,871): Trials at clinicaltrials.gov
Linsitinib (OSI-906): Trials at clinicaltrials.gov
XL228: Trials at clinicaltrials.gov
Cixutumumab (IMC-A12): Trials at clinicaltrials.gov
MEDI-573: Trials at clinicaltrials.gov
This page is always under revision, and more trials will be added as they are identified.
