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GIST Support International - Olaratumab (IMC-3G3)
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Olaratumab (IMC-3G3)

Olaratumab is a monoclonal antibody for PDGFRA.  Llike all monoconal antibodies, it is administered by intravenous infusion.

Manufacturer:  ImClone (a subsidiary of Lilly) http://www/

Definition from NCI Drug Dictionary: olaratumab (IMC-3G3)
A fully human IgG1 monoclonal antibody directed against the platelet-derived growth factor receptor alpha (PDGFR alpha) with potential antineoplastic activity. Olaratumab selectively binds to PDGFR alpha, blocking the binding of its ligand, PDGF; signal transduction downstream of PDGFR through the MAPK and PI3K pathways is inhibited, which may result in inhibition of angiogenesis and tumor cell proliferation. Overexpressed by various cancer cell types, PDGFR is a transmembrane protein tyrosine kinase receptor, consisting of isoforms A and B, that is important in regulating cellular growth and differentiation and angiogenesis.

Phase II trial for GIST

NCT01316263 A Study of IMC-3G3 in Previously Treated Patients With Unresectable and/or Metastatic Gastrointestinal Stromal Tumors   

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