Genasense Perifosine Flavopiridol Bevacizumab (Avastin) Sirolimus (Rapamune) Sorafenib plus 17-AAG Sorafenib plus temsirolimus Imatinib plus Sunitinib 17-AAG (tanespimycin, KOS-953) and Bortezomib

Drugs in Combination

These drugs are in trials in combination with other agents approved or some purposes (though not necessarily for GIST), such as imatinib, sunitinib, or sorafenib.  The purpose is to see whether the combination of the two drugs will improve effectiveness.

Genasense plus imatinib

Perifosine plus imatinib or sunitinib

Flavopiridol plus doxorubicin

Bevacizumab plus imatinib or sunitinib or sorafenib

Sirolimus plus sunitinib

Sorafenib plus 17-AAG

Sorafenib plus Temsirolimus

17-AAG plus Sorafenib

17-N-Allylamino-17-Demethoxygeldanamycin (17-AAG) and Bortezomib